PMID- 32919259
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20210204
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 145
DP  - 2020 Dec
TI  - Pre- and post-diagnostic blood profiles of perfluoroalkyl acids in type 2 
      diabetes mellitus cases and controls.
PG  - 106095
LID - S0160-4120(20)32050-X [pii]
LID - 10.1016/j.envint.2020.106095 [doi]
AB  - BACKGROUND: Studies exploring the associations between perfluoroalkyl acids 
      (PFAAs) and type 2 diabetes mellitus (T2DM) are rather limited and have reported 
      conflicting results. All studies to date, including prospective ones, have relied 
      on a single blood sample to study this association. Similarly, studies 
      investigating how T2DM status may influence the longitudinal changes in PFAA 
      concentrations have not been previously performed. As PFAA concentrations in 
      humans have changed considerably over the last two decades, and as individuals 
      diagnosed with T2DM usually undergo lifestyle changes that could influence these 
      concentrations, a single blood sample may not necessarily reflect the life-time 
      exposure to PFAA concentrations. Hence, repeated measurements from the same 
      individuals will extend our understanding of how PFAAs are associated with T2DM. 
      The present study, therefore, aimed to explore associations between pre- and 
      post-diagnostic PFAA blood profiles and T2DM and assess factors associated with 
      longitudinal changes in PFAAs in T2DM cases and controls. METHODS: Questionnaire 
      data and blood samples from women participating in the Norwegian Women and Cancer 
      study were used to conduct a nested case-control study among 46 T2DM cases 
      matched to 85 non-diabetic controls. PFAAs were measured in blood samples 
      collected prior to (2001/02) and after (2005/6) T2DM diagnosis. We investigated 
      the association between PFAAs and incident and prevalent T2DM using conditional 
      logistic regression. We assessed the longitudinal changes in PFAA concentrations 
      within and between matched cases and controls using t-tests and linear regression 
      models. RESULTS: We observed no significant associations between pre-diagnostic 
      PFAA concentrations and T2DM incidence. Similar results were observed for the 
      post-diagnostic PFAA concentrations and T2DM prevalence. Decrease over time in 
      PFAA concentrations were observed for PFOA and  summation operatorPFOS concentrations, whereas 
      increase over time were observed for PFNA, PFDA and PFUnDA concentrations. 
      Longitudinal trends in PFAA concentrations among T2DM cases were similar to the 
      changes observed in controls. CONCLUSIONS: The study did not find evidence of 
      association between PFAAs and incident or prevalent T2DM. The longitudinal 
      changes in PFAAs concentrations were not influenced by T2DM status.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Charles, Dolley
AU  - Charles D
AD  - Department of Community Medicine, Faculty of Health Sciences, UIT-The Arctic 
      University of Norway, NO-9037 Tromso, Norway. Electronic address: 
      dolley.charles@uit.no.
FAU - Berg, Vivian
AU  - Berg V
AD  - Department of Medical Biology, Faculty of Health Sciences, UIT-The Arctic 
      University of Norway, NO-9037 Tromso, Norway; Department of Laboratory Medicine, 
      Division of Diagnostic Services, University Hospital of North-Norway, NO-9038 
      Tromso, Norway.
FAU - Nost, Therese H
AU  - Nost TH
AD  - Department of Community Medicine, Faculty of Health Sciences, UIT-The Arctic 
      University of Norway, NO-9037 Tromso, Norway.
FAU - Huber, Sandra
AU  - Huber S
AD  - Department of Laboratory Medicine, Division of Diagnostic Services, University 
      Hospital of North-Norway, NO-9038 Tromso, Norway.
FAU - Sandanger, Torkjel M
AU  - Sandanger TM
AD  - Department of Community Medicine, Faculty of Health Sciences, UIT-The Arctic 
      University of Norway, NO-9037 Tromso, Norway.
FAU - Rylander, Charlotta
AU  - Rylander C
AD  - Department of Community Medicine, Faculty of Health Sciences, UIT-The Arctic 
      University of Norway, NO-9037 Tromso, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200909
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Caprylates
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Female
MH  - *Fluorocarbons
MH  - Humans
MH  - Prospective Studies
OTO - NOTNLM
OT  - Longitudinal assessment
OT  - Perfluoroalkyl acids
OT  - Perfluoroalkyl substances
OT  - Pre- and post-diagnostic associations
OT  - Repeated measurements
OT  - Type 2 diabetes mellitus
EDAT- 2020/09/13 06:00
MHDA- 2021/02/05 06:00
CRDT- 2020/09/12 20:15
PHST- 2020/05/09 00:00 [received]
PHST- 2020/08/24 00:00 [revised]
PHST- 2020/08/25 00:00 [accepted]
PHST- 2020/09/13 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2020/09/12 20:15 [entrez]
AID - S0160-4120(20)32050-X [pii]
AID - 10.1016/j.envint.2020.106095 [doi]
PST - ppublish
SO  - Environ Int. 2020 Dec;145:106095. doi: 10.1016/j.envint.2020.106095. Epub 2020 
      Sep 9.