PMID- 32919401
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20220417
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 46
IP  - 4
DP  - 2021 Mar
TI  - Endogenous theta stimulation during meditation predicts reduced opioid dosing 
      following treatment with Mindfulness-Oriented Recovery Enhancement.
PG  - 836-843
LID - 10.1038/s41386-020-00831-4 [doi]
AB  - Veterans experience chronic pain at greater rates than the rest of society and 
      are more likely to receive long-term opioid therapy (LTOT), which, at high doses, 
      is theorized to induce maladaptive neuroplastic changes that attenuate 
      self-regulatory capacity and exacerbate opioid dose escalation. Mindfulness 
      meditation has been shown to modulate frontal midline theta (FMT) and alpha 
      oscillations that are linked with marked alterations in self-referential 
      processing. These adaptive neural oscillatory changes may promote reduced opioid 
      use and remediate the neural dysfunction occasioned by LTOT. In this study, we 
      used electroencephalography (EEG) to assess the effects of a mindfulness-based, 
      cognitive training intervention for opioid misuse, Mindfulness-Oriented Recovery 
      Enhancement (MORE), on alpha and theta power and FMT coherence during meditation. 
      We then examined whether these neural effects were associated with reduced opioid 
      dosing and changes in self-referential processing. Before and after 8 weeks of 
      MORE or a supportive psychotherapy control, veterans receiving LTOT (N = 62) 
      practiced mindfulness meditation while EEG was recorded. Participants treated 
      with MORE demonstrated significantly increased alpha and theta power (with larger 
      theta power effect sizes) as well as increased FMT coherence relative to those in 
      the control condition-neural changes that were associated with altered 
      self-referential processing. Crucially, MORE significantly reduced opioid dose 
      over time, and this dose reduction was partially statistically mediated by 
      changes in frontal theta power. Study results suggest that mindfulness meditation 
      practice may produce endogenous theta stimulation in the prefrontal cortex, 
      thereby enhancing inhibitory control over opioid dose escalation behaviors.
FAU - Hudak, Justin
AU  - Hudak J
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA.
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA.
FAU - Hanley, Adam W
AU  - Hanley AW
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA.
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA.
FAU - Marchand, William R
AU  - Marchand WR
AD  - Veterans Health Care Administration VISN 19 Whole Health Flagship site located at 
      the VA Salt Lake City Health Care System, 500 Foothill, Salt Lake City, UT, 
      84148, USA.
AD  - Department of Psychiatry, University of Utah School of Medicine, 501 Chipeta Way, 
      Salt Lake City, UT, 84108, USA.
FAU - Nakamura, Yoshio
AU  - Nakamura Y
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA.
AD  - Department of Anesthesiology, Division of Pain Medicine, Pain Research Center, 
      University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.
FAU - Yabko, Brandon
AU  - Yabko B
AD  - Veterans Health Care Administration VISN 19 Whole Health Flagship site located at 
      the VA Salt Lake City Health Care System, 500 Foothill, Salt Lake City, UT, 
      84148, USA.
AD  - Department of Psychiatry, University of Utah School of Medicine, 501 Chipeta Way, 
      Salt Lake City, UT, 84108, USA.
FAU - Garland, Eric L
AU  - Garland EL
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, Salt Lake City, UT, USA. eric.garland@socwk.utah.edu.
AD  - College of Social Work, University of Utah, Salt Lake City, UT, USA. 
      eric.garland@socwk.utah.edu.
AD  - Veterans Health Care Administration VISN 19 Whole Health Flagship site located at 
      the VA Salt Lake City Health Care System, 500 Foothill, Salt Lake City, UT, 
      84148, USA. eric.garland@socwk.utah.edu.
LA  - eng
GR  - R01 DA042033/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200912
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Analgesics, Opioid)
SB  - IM
EIN - Neuropsychopharmacology. 2020 Dec 16;:. PMID: 33328592
MH  - Analgesics, Opioid
MH  - *Chronic Pain
MH  - Electroencephalography
MH  - Humans
MH  - *Meditation
MH  - *Mindfulness
PMC - PMC8026958
EDAT- 2020/09/13 06:00
MHDA- 2021/06/24 06:00
PMCR- 2020/09/12
CRDT- 2020/09/12 20:20
PHST- 2020/06/12 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/08/11 00:00 [revised]
PHST- 2020/09/13 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/09/12 20:20 [entrez]
PHST- 2020/09/12 00:00 [pmc-release]
AID - 10.1038/s41386-020-00831-4 [pii]
AID - 831 [pii]
AID - 10.1038/s41386-020-00831-4 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2021 Mar;46(4):836-843. doi: 10.1038/s41386-020-00831-4. 
      Epub 2020 Sep 12.