PMID- 32919655
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 117
DP  - 2020 Dec
TI  - Injectable in situ forming thermo-responsive graphene based hydrogels for cancer 
      chemo-photothermal therapy and NIR light-enhanced antibacterial applications.
PG  - 111294
LID - S0928-4931(20)33212-4 [pii]
LID - 10.1016/j.msec.2020.111294 [doi]
AB  - Functionalized graphene oxide (GO) and reduced GO (rGO) based nanomaterials hold 
      a great potential for cancer photothermal therapy. However, their systemic 
      administration has been associated with an accelerated blood clearance and/or 
      with suboptimal tumor uptake. To address these limitations, the local delivery of 
      GO/rGO to the tumor site by 3D matrices arises as a promising strategy. In this 
      work, injectable chitosan-agarose in situ forming thermo-responsive hydrogels 
      incorporating GO (thermogel-GO) or rGO (thermogel-rGO) were prepared for the 
      first time. The hydrogels displayed suitable injectability and gelation time, as 
      well as good physicochemical properties and cytocompatibility. When irradiated 
      with near infrared (NIR) light, the thermogel-rGO produced a 3.8-times higher 
      temperature increase than thermogel-GO, thus decreasing breast cancer cells' 
      viability to 60%. By incorporating an optimized molar ratio of the 
      Doxorubicin:Ibuprofen combination on thermogel-rGO, this formulation mediated a 
      chemo-photothermal effect that further diminished cancer cells' viability to 34%. 
      In addition, the hydrogels' antibacterial activity was further enhanced upon NIR 
      laser irradiation, which is an important feature considering the possible risk of 
      infection at the site of administration. Overall, thermogel-rGO is a promising 
      injectable in situ forming hydrogel for combinatorial chemo-photothermal therapy 
      of breast cancer cells and NIR light enhanced antibacterial applications.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Lima-Sousa, Rita
AU  - Lima-Sousa R
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal.
FAU - de Melo-Diogo, Duarte
AU  - de Melo-Diogo D
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal. Electronic address: 
      demelodiogo@fcsaude.ubi.pt.
FAU - Alves, Catia G
AU  - Alves CG
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal.
FAU - Cabral, Catia S D
AU  - Cabral CSD
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal.
FAU - Miguel, Sonia P
AU  - Miguel SP
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal; CPIRN-IPG - Centro de Potencial e Inovacao 
      de Recursos Naturais, Instituto Politecnico da Guarda, 6300-559 Guarda, Portugal.
FAU - Mendonca, Antonio G
AU  - Mendonca AG
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal; Departamento de Quimica, Universidade da 
      Beira Interior, 6201-001 Covilha, Portugal.
FAU - Correia, Ilidio J
AU  - Correia IJ
AD  - CICS-UBI - Centro de Investigacao em Ciencias da Saude, Universidade da Beira 
      Interior, 6200-506 Covilha, Portugal; CIEPQPF - Departamento de Engenharia 
      Quimica, Universidade de Coimbra, 3030-790 Coimbra, Portugal. Electronic address: 
      icorreia@ubi.pt.
LA  - eng
PT  - Journal Article
DEP - 20200724
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydrogels)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - *Graphite
MH  - Hydrogels
MH  - *Neoplasms
MH  - Phototherapy
MH  - Photothermal Therapy
OTO - NOTNLM
OT  - Antibacterial activity
OT  - Cancer
OT  - Chemo-photothermal therapy
OT  - Graphene family nanomaterials
OT  - Injectable hydrogel
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/09/14 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/13 20:26
PHST- 2020/02/21 00:00 [received]
PHST- 2020/07/06 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/09/13 20:26 [entrez]
PHST- 2020/09/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0928-4931(20)33212-4 [pii]
AID - 10.1016/j.msec.2020.111294 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2020 Dec;117:111294. doi: 
      10.1016/j.msec.2020.111294. Epub 2020 Jul 24.