PMID- 32919864
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211123
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 34
IP  - 12
DP  - 2020 Dec
TI  - Association of non-HDL-C/HDL-C ratio and its dynamic changes with incident type 2 
      diabetes mellitus: The Rural Chinese Cohort Study.
PG  - 107712
LID - S1056-8727(20)30480-3 [pii]
LID - 10.1016/j.jdiacomp.2020.107712 [doi]
AB  - BACKGROUND: We aimed to evaluate the association of the ratio of non-high-density 
      lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) 
      and its dynamic changes with incident type 2 diabetes mellitus (T2DM). METHODS: A 
      total of 11,487 nondiabetic participants >/=18 years old in rural China were 
      recruited in 2007-2008 and followed up in 2013-2014. A Cox proportional-hazards 
      model was used to assess the risk of incident T2DM by quartiles of baseline 
      non-HDL-C/HDL-C ratio and dynamic absolute and relative changes in 
      non-HDL-C/HDL-C ratio, estimating hazard ratios (HRs) and 95% confidence 
      intervals (CIs). RESULTS: Risk of incident T2DM was increased with quartiles 2, 
      3, and 4 versus quartile 1 of baseline non-HDL-C/HDL-C ratio (HR 1.46 [95% CI 
      1.08-1.98], 1.51 [1.12-2.03], and 2.16 [1.62-2.88], P(trend) < 0.001). As 
      compared with stable non-HDL-C/HDL-C ratio during follow-up, an absolute gain in 
      non-HDL-C/HDL-C ratio was associated with increased risk of T2DM (HR 1.67 [95% CI 
      1.25-2.24] for quartile 3 and 2.00 [1.52-2.61] for quartile 4). A relative 
      increase in non-HDL-C/HDL-C ratio was also associated with increased risk of T2DM 
      (HR 1.56 [95% CI 1.19-2.04] for quartile 3 and 1.97 [1.49-2.60] for quartile 4). 
      Subgroup analyses showed that the association of non-HDL-C/HDL-C ratio with T2DM 
      risk remained consistent. CONCLUSIONS: Increased non-HDL-C/HDL-C ratio is 
      associated with increased risk of incident T2DM among rural Chinese adults, so 
      the index may be an important indicator for identifying individuals at T2DM risk.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Han, Minghui
AU  - Han M
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Li, Quanman
AU  - Li Q
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Qie, Ranran
AU  - Qie R
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Guo, Chunmei
AU  - Guo C
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Zhou, Qionggui
AU  - Zhou Q
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Tian, Gang
AU  - Tian G
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Huang, Shengbing
AU  - Huang S
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Ren, Yongcheng
AU  - Ren Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of 
      Epidemiology, School of Public Health, Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of 
      Epidemiology, School of Public Health, Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Liu, Dechen
AU  - Liu D
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China; Department of 
      Epidemiology, School of Public Health, Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Zhang, Dongdong
AU  - Zhang D
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, People's Republic of China.
FAU - Liu, Leilei
AU  - Liu L
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Liu, Feiyan
AU  - Liu F
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Chen, Xu
AU  - Chen X
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Cheng, Cheng
AU  - Cheng C
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Yang, Xingjin
AU  - Yang X
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Feng, Yifei
AU  - Feng Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Liu, Yu
AU  - Liu Y
AD  - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Li, Honghui
AU  - Li H
AD  - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Sun, Xizhuo
AU  - Sun X
AD  - The Affiliated Luohu Hospital of Shenzhen University Health Science Center, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Qin, Pei
AU  - Qin P
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Chen, Qing
AU  - Chen Q
AD  - Department of Mental Health, Bao'an Chronic Diseases Prevent and Cure Hospital, 
      Shenzhen, Guangdong, People's Republic of China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Epidemiology, School of Public Health, Shenzhen University Health 
      Science Center, Shenzhen, Guangdong, People's Republic of China.
FAU - Hu, Dongsheng
AU  - Hu D
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
FAU - Lu, Jie
AU  - Lu J
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic 
      address: hanyaa800@zzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200824
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - J Diabetes Complications. 2020 Dec;34(12):107755. PMID: 33082076
MH  - Adult
MH  - China/epidemiology
MH  - Cholesterol/*blood
MH  - Cholesterol, HDL/*blood
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Humans
MH  - Risk Factors
MH  - Rural Population
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - Dynamic change
OT  - Non-HDL-C/HDL-C ratio
OT  - Prospective cohort study
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no competing 
      interests.
EDAT- 2020/09/14 06:00
MHDA- 2021/11/24 06:00
CRDT- 2020/09/13 20:27
PHST- 2020/03/09 00:00 [received]
PHST- 2020/06/03 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/09/14 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2020/09/13 20:27 [entrez]
AID - S1056-8727(20)30480-3 [pii]
AID - 10.1016/j.jdiacomp.2020.107712 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2020 Dec;34(12):107712. doi: 
      10.1016/j.jdiacomp.2020.107712. Epub 2020 Aug 24.