PMID- 32920061
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 81
IP  - 5
DP  - 2020 Nov
TI  - Fecal Microbiota Transplantation for multidrug-resistant organism: Efficacy and 
      Response prediction.
PG  - 719-725
LID - S0163-4453(20)30597-1 [pii]
LID - 10.1016/j.jinf.2020.09.003 [doi]
AB  - OBJECTIVES: The increasing prevalence of multidrug-resistant microorganisms 
      (MDRO) is increasing the frequency of poor clinical outcomes, prolonging 
      hospitalizations, and raising healthcare costs. This study evaluated the 
      eradication efficacy of fecal microbiota transplantation (FMT) and identified 
      microbial and functional biomarkers of MDRO decolonization. METHODS: Fecal 
      solution obtained from healthy unrelated donors was infused in the participants' 
      guts which had been colonized with carbapenemase-producing enterobacteriacea 
      (CPE), vancomycin-resistant enterococci (VRE), or both CPE and VRE. Fecal samples 
      from recipients were collected and microbiome changes before and after FMT were 
      assessed. RESULTS: Twenty-four (68.6%) out of 35 patients were decolonized within 
      one year of receiving FMT. Multivariate analysis showed that FMT (FMT: hazard 
      ratio (HR) = 5.343, 95% confidence interval (CI) = 1.877-15.212, p = 0.002) and 
      MDRO types (CPE: HR = 11.146, 95% CI = 2.420-51.340, p = 0.002; CPE/VRE: 
      HR = 2.948, 95% CI = 1.200-7.246, p = 0.018; VRE served as the reference) were 
      significant independent factors associated with time to decolonization. 
      Microbiota analysis showed higher richness and biodiversity before FMT resulted 
      in VRE decolonization. The species Clostridium ramosum and the genuses 
      Anaerostipes and Eisenbergiella could serve as taxonomic biomarkers and K02017 
      could serve as a functional biomarker for VRE clearance. CONCLUSION: FMT is an 
      effective way to decolonize MDRO and its effectiveness may be predicted by 
      microbiome analysis.
CI  - Copyright (c) 2020 The British Infection Association. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Seong, Hye
AU  - Seong H
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea; Division of Infectious 
      Diseases, Department of Internal Medicine, Korea University College of Medicine, 
      Seoul, South Korea.
FAU - Lee, Sang Kil
AU  - Lee SK
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, South Korea.
FAU - Cheon, Jae Hee
AU  - Cheon JH
AD  - Division of Gastroenterology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, South Korea.
FAU - Yong, Dong Eun
AU  - Yong DE
AD  - Department of Laboratory Medicine and Research Institute of Bacterial Resistance, 
      Yonsei University College of Medicine, Seoul, South Korea.
FAU - Koh, Hong
AU  - Koh H
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 
      Severance Children's Hospital, Severance Pediatric Liver Disease Research Group, 
      Yonsei University College of Medicine, Seoul, South Korea.
FAU - Kang, Yun Koo
AU  - Kang YK
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 
      Yonsei University Wonju College of Medicine, Wonju, South Korea.
FAU - Jeong, Woo Young
AU  - Jeong WY
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Lee, Woon Ji
AU  - Lee WJ
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Sohn, Yujin
AU  - Sohn Y
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Cho, Yunsuk
AU  - Cho Y
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Hyun, Jong Hoon
AU  - Hyun JH
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Baek, Yae Jee
AU  - Baek YJ
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Kim, Moo Hyun
AU  - Kim MH
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Kim, Jung Ho
AU  - Kim JH
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Ahn, Jin Young
AU  - Ahn JY
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Ku, Nam Su
AU  - Ku NS
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Jeong, Su Jin
AU  - Jeong SJ
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Yeom, Joon Sup
AU  - Yeom JS
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Cho, Min Seok
AU  - Cho MS
AD  - ChunLab, Inc., JW Tower, 2477, Nambusunhwan-ro, Seocho-gu, Seoul, South Korea.
FAU - Lee, Je Hee
AU  - Lee JH
AD  - ChunLab, Inc., JW Tower, 2477, Nambusunhwan-ro, Seocho-gu, Seoul, South Korea.
FAU - Kim, Byung-Yong
AU  - Kim BY
AD  - ChunLab, Inc., JW Tower, 2477, Nambusunhwan-ro, Seocho-gu, Seoul, South Korea.
FAU - Choi, Jun Yong
AU  - Choi JY
AD  - Division of Infectious Diseases, Department of Internal Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea. Electronic address: 
      seran@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200911
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - Erysipelatoclostridium ramosum
SB  - IM
MH  - Drug Resistance, Multiple, Bacterial
MH  - Fecal Microbiota Transplantation
MH  - Feces
MH  - Firmicutes
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Vancomycin-Resistant Enterococci
OTO - NOTNLM
OT  - carbapenemase-producing enterobacteriaceae
OT  - disease eradication
OT  - fecal microbiota transplantation
OT  - gut microbiome
OT  - vancomycin-resistant enterococci
EDAT- 2020/09/14 06:00
MHDA- 2021/03/19 06:00
CRDT- 2020/09/13 20:29
PHST- 2020/06/18 00:00 [received]
PHST- 2020/08/30 00:00 [revised]
PHST- 2020/09/07 00:00 [accepted]
PHST- 2020/09/14 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2020/09/13 20:29 [entrez]
AID - S0163-4453(20)30597-1 [pii]
AID - 10.1016/j.jinf.2020.09.003 [doi]
PST - ppublish
SO  - J Infect. 2020 Nov;81(5):719-725. doi: 10.1016/j.jinf.2020.09.003. Epub 2020 Sep 
      11.