PMID- 32920101
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 169
DP  - 2020 Nov
TI  - Evidence to support the classification of hyperglycemia first detected in 
      pregnancy to predict diabetes 6-12 weeks postpartum: A single center cohort 
      study.
PG  - 108421
LID - S0168-8227(20)30674-4 [pii]
LID - 10.1016/j.diabres.2020.108421 [doi]
AB  - AIMS: Diagnostic criteria for type 2 diabetes mellitus (T2DM) applied to women 
      with gestational diabetes mellitus (GDM) may predict postpartum T2DM but requires 
      validation. METHODS: Women with GDM aged >/= 18-years were prospectively evaluated 
      6-12 weeks after delivery at Tygerberg Hospital, Cape Town, South-Africa 
      (November 2015- December 2018). Glucose status at GDM diagnosis was categorized 
      into i) International Association for Diabetes in Pregnancy Study Group (IADPSG) 
      T2DM (fasting glucose >/= 7 mmol/L and/or 2hr-glucose >/= 11.1 mmol/L) or ii) 
      modified National Institute for Care Excellence (NICE) GDM (fasting 
      glucose >/= 5.6 mmol/L-6.9 mmol/L and/or 2hr-glucose >/= 7.8 mmol/L-11 mmol/L) and 
      compared with postpartum OGTT. RESULTS: IADPSG T2DM and NICE GDM was present in 
      35% (n = 64) and 65% (n = 117) of the 181 women who completed the 8 +/- 2 weeks 
      postpartum evaluation respectively. Postpartum, the prevalence of T2DM and 
      prediabetes was 26% (n = 47/181) and 15% (n = 28). Antenatal IADPSG T2DM 
      categorization identified 31/47 women with postpartum T2DM (sensitivity 75%; 
      specificity 48%). All of the modified NICE GDM category women who developed T2DM 
      (n = 16/117) had elevations of both fasting and 2hr-glucose values antenatally. 
      CONCLUSION: The utility of the IADPSG T2DM criteria to predict T2DM postpartum is 
      confirmed. Women with both fasting and 2hr-glucose values above GDM cut-offs 
      emerged as another high-risk category.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Coetzee, Ankia
AU  - Coetzee A
AD  - Department of Medicine, Division of Endocrinology Stellenbosch University and 
      Tygerberg Hospital, PO Box 19063 Tygerberg 7505, Cape Town, South Africa. 
      Electronic address: ankiac@sun.ac.za.
FAU - Sadhai, Nishendra
AU  - Sadhai N
AD  - Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape 
      Town, South Africa.
FAU - Mason, Deidre
AU  - Mason D
AD  - Department of Obstetrics & Gynecology, Stellenbosch University and Tygerberg 
      Hospital, Cape Town, South Africa. Electronic address: dmason@sun.ac.za.
FAU - Hall, David R
AU  - Hall DR
AD  - Department of Obstetrics & Gynecology, Stellenbosch University and Tygerberg 
      Hospital, PO Box 19063 Tygerberg 7505, Cape Town, South Africa. Electronic 
      address: drh@sun.ac.za.
FAU - Conradie, Magda
AU  - Conradie M
AD  - Department of Medicine, Division of Endocrinology Stellenbosch University and 
      Tygerberg Hospital, PO Box 19063 Tygerberg 7505, Cape Town, South Africa. 
      Electronic address: mc4@sun.ac.za.
LA  - eng
PT  - Journal Article
DEP - 20200910
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology
MH  - Diabetes, Gestational
MH  - Female
MH  - Glucose Tolerance Test/*methods
MH  - Humans
MH  - Hyperglycemia/*classification
MH  - Postpartum Period
MH  - Pregnancy
MH  - Prospective Studies
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - Hyperglycemia first detected in pregnancy
OT  - Overt diabetes mellitus
OT  - Postpartum diabetes
OT  - Predictive factors
OT  - Prevalence
EDAT- 2020/09/14 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/09/13 20:29
PHST- 2020/04/03 00:00 [received]
PHST- 2020/06/24 00:00 [revised]
PHST- 2020/09/03 00:00 [accepted]
PHST- 2020/09/14 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/09/13 20:29 [entrez]
AID - S0168-8227(20)30674-4 [pii]
AID - 10.1016/j.diabres.2020.108421 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 Nov;169:108421. doi: 10.1016/j.diabres.2020.108421. 
      Epub 2020 Sep 10.