PMID- 32921221
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20210311
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 61
IP  - 14
DP  - 2020 Dec
TI  - Clinicopathological and prognostic significance of BCL2, BCL6, MYC, and IRF4 copy 
      number gains and translocations in follicular lymphoma: a study by FISH analysis.
PG  - 3342-3350
LID - 10.1080/10428194.2020.1815017 [doi]
AB  - BCL2 translocation is the genetic hallmark of follicular lymphoma (FL). Besides 
      BCL2 translocation, copy number (CN) gains and translocations of BCL6, MYC, and 
      IRF4 have also been detected in FL, but there is little information regarding 
      their prognostic significance. This retrospective study used fluorescence in situ 
      hybridization (FISH) to analyze BCL2, BCL6, MYC, and IRF4 translocations and CN 
      gains in 105 FL cases. Genetic translocations were detected for BCL2 (n = 64; 
      72.7%), BCL6 (n = 14; 15.9%), and MYC (n = 2; 2.3%); no case showed IRF4 
      translocation. Overall, 23 (26.1%), 30 (34.1%), 12 (13.8%), and 10 (11.0%) cases 
      showed CN gains in BCL2, BCL6, MYC, and IRF4, respectively. BCL6 CN gain was a 
      prognostic factor for worse overall survival, demonstrating a trend toward 
      significance in multivariate analysis (HR =8.769, p = 0.056). BCL6 CN gain in FL 
      might be associated with aggressive biologic behavior.
FAU - Kim, Meejeong
AU  - Kim M
AUID- ORCID: 0000-0002-1232-8439
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Hwang, Hee Sang
AU  - Hwang HS
AUID- ORCID: 0000-0001-9486-9214
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Son, Eun Mi
AU  - Son EM
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Cho, Hyungwoo
AU  - Cho H
AD  - Department of Oncology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Yoon, Dok Hyun
AU  - Yoon DH
AD  - Department of Oncology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Suh, Cheolwon
AU  - Suh C
AUID- ORCID: 0000-0002-9178-4431
AD  - Department of Oncology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Park, Chan Sik
AU  - Park CS
AUID- ORCID: 0000-0001-9783-4498
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Go, Heounjeong
AU  - Go H
AUID- ORCID: 0000-0003-0412-8709
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Huh, Jooryung
AU  - Huh J
AUID- ORCID: 0000-0002-2148-5778
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200913
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (BCL2 protein, human)
RN  - 0 (BCL6 protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (interferon regulatory factor-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - DNA Copy Number Variations
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - Genes, myc/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Interferon Regulatory Factors/*genetics/metabolism
MH  - Lymphoma, Follicular/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/*genetics/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6/*genetics/metabolism
MH  - Retrospective Studies
MH  - Tissue Array Analysis
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - BCL6
OT  - copy number
OT  - fluorescence in situ hybridization
OT  - follicular lymphoma
OT  - translocation
EDAT- 2020/09/15 06:00
MHDA- 2021/03/12 06:00
CRDT- 2020/09/14 05:30
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2020/09/14 05:30 [entrez]
AID - 10.1080/10428194.2020.1815017 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2020 Dec;61(14):3342-3350. doi: 10.1080/10428194.2020.1815017. 
      Epub 2020 Sep 13.