PMID- 32921728
OWN - NLM
STAT- MEDLINE
DCOM- 20200922
LR  - 20210517
IS  - 2531-6745 (Electronic)
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 91
IP  - 3
DP  - 2020 Sep 7
TI  - The "perfect" storm: Current evidence on pediatric inflammatory multisystem 
      disease during SARS-CoV-2 pandemic.
PG  - e2020034
LID - 10.23750/abm.v91i3.10360 [doi]
AB  - Current data suggest that during the global pandemic of COVID 19 children are 
      less affected than adults and most of them are asymptomatic or with mild 
      symptoms. However, recently, cases of pediatric patients who have developed 
      severe inflammatory syndrome temporally related to SARS-CoV-2 have been reported 
      both in USA and Europe. These reports, although sharing features with other 
      pediatric syndromes such as Kawasaki disease (KD), Kawasaki disease shock 
      syndrome (KDSS), macrophage activated syndrome (MAS) and shock toxic syndrome 
      (TSS), seem to outline a novel entity syndrome, characterized by cytokine storm 
      with elevated inflammatory markers and typical clinical finding. Clinical 
      characteristics are greater median age than KD, higher frequency of cardiac 
      involvement and gastrointestinal symptoms, lower frequency of coronary anomalies. 
      We report a summary of the current evidence about clinical features, 
      pathogenesis, therapy strategies and outcome of this novel syndrome.
FAU - Lami, Francesca
AU  - Lami F
AD  - Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, 
      Children and Adults. University of Modena and Reggio Emilia. 
      lami.francesca@aou.mo.it.
FAU - Scalabrini, Ilaria
AU  - Scalabrini I
AD  - Post-graduate school of Pediatrics, Department of Medical and Surgical Sciences 
      of the Mother, Children and Adults. University of Modena and Reggio Emilia. 
      ilaria.scalabrini@gmail.com.
FAU - Lucaccioni, Laura
AU  - Lucaccioni L
AD  - Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, 
      Children and Adults. University of Modena and Reggio Emilia, Via del Pozzo n. 71, 
      41124, Modena, Italy. laura.lucaccioni@unimore.it.
FAU - Iughetti, Lorenzo
AU  - Iughetti L
AD  - Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, 
      Children and Adults. University of Modena and Reggio Emilia, Modena, Italy. 
      lorenzo.iughetti@unimore.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200907
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
CIN - Acta Biomed. 2021 May 12;92(2):e2021016. PMID: 33988161
MH  - *Betacoronavirus
MH  - Biomarkers/blood
MH  - COVID-19
MH  - Child
MH  - Coronavirus Infections/blood/*epidemiology
MH  - Cytokines/*blood
MH  - Humans
MH  - Mucocutaneous Lymph Node Syndrome/blood/*epidemiology
MH  - *Pandemics
MH  - Pneumonia, Viral/blood/*epidemiology
MH  - SARS-CoV-2
PMC - PMC7717011
COIS- Each author declares that he or she has no commercial associations (e.g. 
      consultancies, stock ownership, equity interest, patent/licensing arrangement 
      etc.) that might pose a conflict of interest in connection with the submitted 
      article
EDAT- 2020/09/15 06:00
MHDA- 2020/09/23 06:00
PMCR- 2020/01/01
CRDT- 2020/09/14 05:47
PHST- 2020/07/30 00:00 [received]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/09/14 05:47 [entrez]
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2020/09/23 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ACTA-91-34 [pii]
AID - 10.23750/abm.v91i3.10360 [doi]
PST - epublish
SO  - Acta Biomed. 2020 Sep 7;91(3):e2020034. doi: 10.23750/abm.v91i3.10360.