PMID- 32922017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 16
DP  - 2020
TI  - A Prospective, Randomized and Controlled Study on Tissue Adhesive for Skin 
      Incision in Total Knee Arthroplasty.
PG  - 795-802
LID - 10.2147/TCRM.S260007 [doi]
AB  - BACKGROUND: The study focusing on the tissue adhesive in total knee arthroplasty 
      (TKA) was rare. This study aimed to evaluate the clinical outcomes and economic 
      costs of tissue adhesive when acting as the adjunct to standard incision closure 
      in TKA. PATIENTS AND METHODS: From September 2019 to November 2019, we 
      prospectively enrolled the consecutive patients who underwent simultaneous 
      bilateral TKA in our institute. The allocation using the tissue adhesive was done 
      after the subcuticular suture in right knee first and another method was applied 
      in the left knee automatically. The patients' demographics, length of stay (LOS), 
      times of dressing changes and incision-related cost, range of motion (ROM), 
      incision-related complications and incision evaluation scores were recorded. 
      RESULTS: Thirty-two patients were enrolled in this study and followed at two 
      months after surgery. In the knees of tissue adhesive, the times of dressing 
      change and patient scar assessment scores (PSAS) were significantly less than 
      those standard skin closure (p=0.000; p=0.003). Although there were no 
      significant differences of the delayed discharge, incision-related cost, ROM, 
      incision-related complications and Vancouver scar score (VSS) between two groups, 
      65.6% (21/32) patients preferred the tissue adhesive and only 15.6% (5/32) 
      patients preferred the standard incision closure. CONCLUSION: Tissue adhesive 
      could effectively reduce postoperative wound drainage and improve patients' 
      satisfaction rate with no difference in medical costs and ROM in TKA. The 
      application of tissue adhesive and subcuticular sutures might be one safe and 
      convenient method of skin closure in TKA. CHINESE CLINICAL TRIAL REGISTRY: 
      ChiCTR1900025730; Registered 6 September 2019.
CI  - (c) 2020 Kong et al.
FAU - Kong, Xiangpeng
AU  - Kong X
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
FAU - Yang, Minzhi
AU  - Yang M
AUID- ORCID: 0000-0003-3416-0144
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
AD  - Nankai University, Tianjin, People's Republic of China.
FAU - Guo, Renwen
AU  - Guo R
AUID- ORCID: 0000-0002-0514-0921
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
FAU - Chen, Jiying
AU  - Chen J
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
FAU - Chai, Wei
AU  - Chai W
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Orthopaedics, Chinese PLA General Hospital, Beijing, People's 
      Republic of China.
LA  - eng
PT  - Case Reports
PT  - Clinical Trial
DEP - 20200824
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC7457845
OTO - NOTNLM
OT  - dressing change
OT  - incision closure
OT  - tissue adhesive
OT  - total knee arthroplasty
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/09/15 06:00
MHDA- 2020/09/15 06:01
PMCR- 2020/08/24
CRDT- 2020/09/14 05:48
PHST- 2020/04/26 00:00 [received]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/09/14 05:48 [entrez]
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2020/09/15 06:01 [medline]
PHST- 2020/08/24 00:00 [pmc-release]
AID - 260007 [pii]
AID - 10.2147/TCRM.S260007 [doi]
PST - epublish
SO  - Ther Clin Risk Manag. 2020 Aug 24;16:795-802. doi: 10.2147/TCRM.S260007. 
      eCollection 2020.