PMID- 32924077 OWN - NLM STAT- MEDLINE DCOM- 20210618 LR - 20210618 IS - 1573-2630 (Electronic) IS - 0165-5701 (Linking) VI - 41 IP - 2 DP - 2021 Feb TI - Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia. PG - 399-407 LID - 10.1007/s10792-020-01589-w [doi] AB - PURPOSE: To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness. METHODS: Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated. RESULTS: Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (p < 0.05 for all). However, there were no significant differences in RNFL thickness values between the IDA patient group and the control group (p > 0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin. CONCLUSION: It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion. FAU - Kocer, Ali Mert AU - Kocer AM AUID- ORCID: 0000-0001-6847-1560 AD - Ophthalmology Department, Ankara Ulucanlar Eye Training and Research Hospital, 06240, Ankara, Turkey. alimertkocer@gmail.com. FAU - Kiziltoprak, Hasan AU - Kiziltoprak H AD - Ophthalmology Department, Bingol Woman's Health and Children's Hospital, Bingol, Turkey. FAU - Fen, Turgay AU - Fen T AD - Internal Medicine Department, Ankara Training and Research Hospital, Ankara, Turkey. FAU - Goker, Yasin Sakir AU - Goker YS AD - Ophthalmology Department, Ankara Ulucanlar Eye Training and Research Hospital, 06240, Ankara, Turkey. FAU - Acar, Atakan AU - Acar A AD - Ophthalmology Department, Ankara Ulucanlar Eye Training and Research Hospital, 06240, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20200913 PL - Netherlands TA - Int Ophthalmol JT - International ophthalmology JID - 7904294 SB - IM MH - *Anemia, Iron-Deficiency/diagnosis/etiology MH - Humans MH - Nerve Fibers MH - Retina MH - Retinal Ganglion Cells MH - Tomography, Optical Coherence OTO - NOTNLM OT - Iron deficiency anemia OT - Optical coherence tomography angiography OT - Radial peripapillary capillary OT - Retinal nerve fiber layer EDAT- 2020/09/15 06:00 MHDA- 2021/06/22 06:00 CRDT- 2020/09/14 05:58 PHST- 2020/04/11 00:00 [received] PHST- 2020/09/04 00:00 [accepted] PHST- 2020/09/15 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/09/14 05:58 [entrez] AID - 10.1007/s10792-020-01589-w [pii] AID - 10.1007/s10792-020-01589-w [doi] PST - ppublish SO - Int Ophthalmol. 2021 Feb;41(2):399-407. doi: 10.1007/s10792-020-01589-w. Epub 2020 Sep 13.