PMID- 32926060
OWN - NLM
STAT- MEDLINE
DCOM- 20210118
LR  - 20210118
IS  - 1463-9084 (Electronic)
IS  - 1463-9076 (Linking)
VI  - 22
IP  - 37
DP  - 2020 Sep 30
TI  - Magnetic studies of polylactic-co-glicolic acid nanocapsules loaded with selol 
      and gamma-Fe(2)O(3) nanoparticles.
PG  - 21042-21058
LID - 10.1039/d0cp02706e [doi]
AB  - The as-prepared (MSE-NCs sample) and lyophilized (LMSE-NCs sample) 
      polylactic-co-glicolic acid (PLGA) nanocapsules loaded with maghemite (gamma-Fe2O3) 
      nanoparticles and selol (Se-based anticancer drug) were investigated by means of 
      dc magnetization, ac susceptibility and electron spin resonance (ESR) 
      measurements over the temperature range of 4-300 K. The magnetic data of the 
      as-synthesized nanocapsules containing only maghemite nanoparticles (M-NCs 
      sample) or selol (SE-NCs sample) were also collected for comparison. The magnetic 
      nanocapsules reveal perfect superparamagnetic (SPM) behavior only around room 
      temperature; at temperatures lower than 200 K the SPM scaling is not observed and 
      all samples behave as interacting superparamagnetic (ISPM) materials. The 
      evolution from the ISPM to the SPM regime is marked by a steady decrease in the 
      hysteretic properties of all samples, with the temperature dependence of the 
      coercivity decreasing slower than the T1/2 behavior predicted for non-interacting 
      SPM particles. The SPM character of the samples is also confirmed by the 
      occurrence of a maximum in the temperature dependence of both real chi'(T) and 
      imaginary chi''(T) components of the ac magnetic susceptibility, which shifts 
      towards higher temperatures with increasing frequency. Moreover, upon decreasing 
      the temperature the ESR signal shifts to lower fields and gradually broadens, 
      following closely the predictions for the ESR of SPM particles. Additionally, an 
      unusual giant diamagnetic response is observed at low temperatures. The ZFC 
      magnetization is found to reverse its direction and becomes diamagnetic, whereas 
      the FC branch remains positive. Even when compared with usual superconductors, 
      the order of the diamagnetic susceptibility for the lyophilized sample (-10-2 emu 
      g-1 Oe-1) is quite considerable. The nanocapsules herein reported and the 
      presented analysis of their magnetic properties we envisage can support the 
      engineering of magnetic nanocapsules for applications in magnetic drug delivery 
      systems and as magnetic hyperthermia inductors in antitumor therapy.
FAU - Mosiniewicz-Szablewska, Ewa
AU  - Mosiniewicz-Szablewska E
AD  - Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 
      Warsaw, Poland. mosin@ifpan.edu.pl.
FAU - Tedesco, Antonio C
AU  - Tedesco AC
FAU - Suchocki, Piotr
AU  - Suchocki P
FAU - Morais, Paulo C
AU  - Morais PC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Phys Chem Chem Phys
JT  - Physical chemistry chemical physics : PCCP
JID - 100888160
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Ferric Compounds)
RN  - 0 (Nanocapsules)
RN  - 0 (Selenium Compounds)
RN  - 176669-95-7 (selol)
RN  - 1K09F3G675 (ferric oxide)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
SB  - IM
MH  - Antineoplastic Agents/chemistry
MH  - Drug Carriers/*chemistry
MH  - Ferric Compounds/*chemistry
MH  - Magnetic Iron Oxide Nanoparticles/*chemistry
MH  - Magnetic Phenomena
MH  - Nanocapsules/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
MH  - Selenium Compounds/*chemistry
MH  - Temperature
EDAT- 2020/09/15 06:00
MHDA- 2021/01/20 06:00
CRDT- 2020/09/14 15:46
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2020/09/14 15:46 [entrez]
AID - 10.1039/d0cp02706e [doi]
PST - ppublish
SO  - Phys Chem Chem Phys. 2020 Sep 30;22(37):21042-21058. doi: 10.1039/d0cp02706e.