PMID- 32927103
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20220205
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 141
DP  - 2020 Dec
TI  - Bone tissue material composition is compromised in premenopausal women with Type 
      2 diabetes.
PG  - 115634
LID - S8756-3282(20)30414-2 [pii]
LID - 10.1016/j.bone.2020.115634 [doi]
AB  - Type 2 diabetes mellitus (T2DM) patients are at an increased risk of fracture 
      despite normal to high bone mineral density (BMD) values. In this cross-sectional 
      study we establish bone compositional properties in tetracycline labeled iliac 
      crest biopsies from premenopausal women diagnosed with T2DM (N = 26). Within 
      group comparisons were made as a function of tissue age (TA), presence of chronic 
      complications (CC), glycosylated haemoglobin (HbA1c) levels, and morphometric 
      fracture (MFx). We also compared these data at actively trabecular bone forming 
      surfaces against sex- and age-matched healthy controls (N = 32). The bone quality 
      indices determined by Raman microspectroscopic analysis were: mineral/matrix 
      (MM), tissue water content (nanoporosity; NanoP), mineral maturity/crystallinity 
      (MMC), and glycosaminoglycan (GAG), pyridinoline (Pyd), N-(carboxymethyl)lysine 
      (CML), and pentosidine (PEN) content. Within the T2DM group, at the oldest 
      tissue, CML and PEN contents were significantly elevated in the cancellous 
      compared to cortical compartment. The outcomes were not dependent on MFx. On the 
      other hand, both were significantly elevated in patients with CC, as well as 
      those with HbA1c levels > 7%. At actively forming surfaces, the cortical 
      compartment had higher NanoP compared to cancellous. Still within the T2DM group, 
      patients with MFx had significantly elevated MM and GAGs compared to the ones 
      that did not. At actively forming trabecular surfaces, compared to healthy women, 
      T2DM patients had elevated GAGs content and MMC. The results of this study 
      indicate increased AGEs in those with poor glycation control and chronic 
      complications. Additionally, T2DM patients had elevated MMC and decreased GAGs 
      content compared to healthy controls. These alterations may be contributing to 
      the T2DM inherent elevated fracture risk and suggest a role for hyperglycemia on 
      bone quality.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Rokidi, Stamatia
AU  - Rokidi S
AD  - Ludwig Boltzmann Institute for Osteology at the Hanusch Hospital of OEGK and AUVA 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Andrade, Vicente F C
AU  - Andrade VFC
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil.
FAU - Borba, Victoria
AU  - Borba V
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil.
FAU - Shane, Elizabeth
AU  - Shane E
AD  - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 
      USA.
FAU - Cohen, Adi
AU  - Cohen A
AD  - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 
      USA.
FAU - Zwerina, Jochen
AU  - Zwerina J
AD  - Ludwig Boltzmann Institute for Osteology at the Hanusch Hospital of OEGK and AUVA 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Paschalis, Eleftherios P
AU  - Paschalis EP
AD  - Ludwig Boltzmann Institute for Osteology at the Hanusch Hospital of OEGK and AUVA 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria. Electronic address: lpaschalis@gmx.net.
FAU - Moreira, Carolina A
AU  - Moreira CA
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil; Lab PRO, Bone Histomorphometry, Pro Renal Foundation, Curitiba, 
      Brazil.
LA  - eng
GR  - R01 AR049896/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200911
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
SB  - IM
MH  - Bone Density
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - *Fractures, Bone
MH  - Humans
MH  - Premenopause
OTO - NOTNLM
OT  - Advanced glycation endproducts
OT  - Bone quality
OT  - Raman microspectroscopy
OT  - Type 2 diabetes mellitus
OT  - Vertebral fractures
EDAT- 2020/09/15 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/14 20:13
PHST- 2020/06/23 00:00 [received]
PHST- 2020/09/03 00:00 [revised]
PHST- 2020/09/08 00:00 [accepted]
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/14 20:13 [entrez]
AID - S8756-3282(20)30414-2 [pii]
AID - 10.1016/j.bone.2020.115634 [doi]
PST - ppublish
SO  - Bone. 2020 Dec;141:115634. doi: 10.1016/j.bone.2020.115634. Epub 2020 Sep 11.