PMID- 32927210
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 131
IP  - 11
DP  - 2020 Nov
TI  - Probing interhemispheric dorsal premotor-primary motor cortex interactions with 
      threshold hunting transcranial magnetic stimulation.
PG  - 2551-2560
LID - S1388-2457(20)30444-2 [pii]
LID - 10.1016/j.clinph.2020.07.020 [doi]
AB  - OBJECTIVE: To characterise the effect of altering transcranial magnetic 
      stimulation parameters on the magnitude of interhemispheric inhibition (IHI) from 
      dorsal premotor (PMd) to primary motor cortex (M1). METHOD: We used a fully 
      automated adaptive threshold hunting paradigm to quantify PMd-M1 IHI across a 
      range of conditioning stimulus (CS) intensities (90%, 110%, 130% of resting motor 
      threshold, rMT) and interstimulus intervals (ISIs) (8, 10, 40 ms). M1-M1 IHI was 
      examined with CS intensities of 110%, 120%, and 130% rMT and ISIs of 10 and 
      40 ms. Two test coil orientations (inducing posterior-anterior or 
      anterior-posterior current) were used. RESULTS: PMd-M1 IHI was obtained 
      consistently with posterior-anterior (but not anterior-posterior) test stimuli 
      and increased with CS intensity. M1-M1 IHI was expressed across all conditions 
      and increased with CS intensity when posterior-anterior but not 
      anterior-posterior induced current was used. CONCLUSIONS: The expression of 
      PMd-M1 IHI is contingent on test coil orientation (requiring posterior-anterior 
      induced current) and increases as a function of CS intensity. The expression of 
      M1-M1 IHI is not dependent on test coil orientation. SIGNIFICANCE: We defined a 
      range of parameters that elicit reliable PMd-M1 IHI. This (threshold hunting) 
      methodology may provide a means to quantify premotor-motor pathology and reveal 
      novel quantitative biomarkers.
CI  - Copyright (c) 2020 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Calvert, Glenn H M
AU  - Calvert GHM
AD  - Trinity College Institute of Neuroscience and School of Psychology, Lloyd 
      Building, Trinity College Dublin, Dublin 2, Ireland; School of Psychology, 
      Queen's University Belfast, David Keir Building, 18-30 Malone Road, Belfast BT9 
      5BN, Northern Ireland, UK.
FAU - McMackin, Roisin
AU  - McMackin R
AD  - Academic Unit of Neurology, 152-160 Pearse St., Trinity Biomedical Sciences 
      Institute, Trinity College Dublin, Dublin 2, Ireland.
FAU - Carson, Richard G
AU  - Carson RG
AD  - Trinity College Institute of Neuroscience and School of Psychology, Lloyd 
      Building, Trinity College Dublin, Dublin 2, Ireland; School of Psychology, 
      Queen's University Belfast, David Keir Building, 18-30 Malone Road, Belfast BT9 
      5BN, Northern Ireland, UK. Electronic address: richard.carson@tcd.ie.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200826
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Neural Inhibition/physiology
MH  - Neural Pathways/physiology
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - Adaptive threshold hunting
OT  - Interhemispheric inhibition
OT  - PEST
OT  - Paired pulse
OT  - TMS
OT  - Upper limb
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/09/15 06:00
MHDA- 2021/05/26 06:00
CRDT- 2020/09/14 20:14
PHST- 2020/04/18 00:00 [received]
PHST- 2020/07/06 00:00 [revised]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/09/15 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/09/14 20:14 [entrez]
AID - S1388-2457(20)30444-2 [pii]
AID - 10.1016/j.clinph.2020.07.020 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2020 Nov;131(11):2551-2560. doi: 10.1016/j.clinph.2020.07.020. 
      Epub 2020 Aug 26.