PMID- 32928137
OWN - NLM
STAT- MEDLINE
DCOM- 20210607
LR  - 20210607
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Sep 14
TI  - Reference intervals of gestational sac, yolk sac, embryonic length, embryonic 
      heart rate at 6-10 weeks after in vitro fertilization-embryo transfer.
PG  - 533
LID - 10.1186/s12884-020-03186-2 [doi]
LID - 533
AB  - BACKGROUND: Accurately determining the normal range of early pregnancy markers 
      can help to predict adverse pregnancy outcomes. The variance in ovulation days 
      leads to uncertain accuracy of reference intervals for natural pregnancies. While 
      the gestational age (GA) is accurate estimation during in vitro 
      fertilization-embryo transfer (IVF-ET). Thus, the objective of this research is 
      to construct reference intervals for gestational sac diameter (GSD), yolk sac 
      diameter (YSD), embryonic length (or crown-rump length, CRL) and embryonic heart 
      rate (HR) at 6-10 gestational weeks (GW) after IVF-ET. METHODS: From January 2010 
      to December 2016, 30,416 eligible singleton pregnancies were retrospectively 
      recruited. All included participants had full records of early ultrasound 
      measurements and phenotypically normal live neonates after 37 GW, with birth 
      weights > the 5th percentile for gestational age. The curve-fitting method was 
      used to screen the optimal models to predict GSD, CRL, YSD and HR based on 
      gestational days (GD) and GW. Additionally, the percentile method was used to 
      calculate the 5th, 50th, and 95th percentiles. RESULTS: There were significant 
      associations among GSD, CRL, YSD, HR and GD and GW, the models were 
      GSD = - 29.180 + 1.070 GD (coefficient of determination [R(2)] = 0.796), 
      CRL = - 11.960 - 0.147 GD + 0.011 GD(2) (R(2) = 0.976), YSD = - 2.304 + 0.184 GD 
      - 0.011 GD(2) (R(2) = 0.500), HR = - 350.410 + 15.398 GD - 0.112 GD(2) 
      (R(2) = 0.911); and GSD = - 29.180 + 7.492 GW (R(2) = 0.796), CRL = - 11.960 - 
      1.028 GW + 0.535 GW(2) (R(2) = 0.976), YSD = - 2.304 + 1.288 GW - 0.054 GW(2) 
      (R(2) = 0.500), HR = - 350.410 + 107.788 GW - 5.488 GW(2) (R(2) = 0.911), 
      (p < 0.001). CONCLUSIONS: Reference intervals for GSD, YSD, HR and CRL at 6-10 
      gestational weeks after IVF-ET were established.
FAU - Ouyang, Yan
AU  - Ouyang Y
AD  - College of Life Science, Hunan Normal University, Changsha, China.
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
AD  - Clinical Research Center For Reproduction and Genetics in Hunan Province, 
      Changsha, China.
FAU - Qin, Jiabi
AU  - Qin J
AD  - Department of Epidemiology and Health Statistics, Xiangya School of Public 
      Health, Central South University, Changsha, China.
FAU - Lin, Ge
AU  - Lin G
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
AD  - Clinical Research Center For Reproduction and Genetics in Hunan Province, 
      Changsha, China.
FAU - Xiang, Shuanglin
AU  - Xiang S
AD  - College of Life Science, Hunan Normal University, Changsha, China.
FAU - Li, Xihong
AU  - Li X
AUID- ORCID: 0000-0002-0986-760X
AD  - Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. 
      xihongliyxk@163.com.
AD  - Clinical Research Center For Reproduction and Genetics in Hunan Province, 
      Changsha, China. xihongliyxk@163.com.
LA  - eng
GR  - 2019M652778/Postdoctoral Science Foundation of Jiangsu Province/
GR  - C20180289/Health and Family Planning Commission of Sichuan Province/
GR  - 2020JJ5992/the Natural Science Foundation of Hunan Province,China/
PT  - Journal Article
DEP - 20200914
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Crown-Rump Length
MH  - *Embryo Transfer
MH  - Embryo, Mammalian/*anatomy & histology/*physiology
MH  - Female
MH  - *Fertilization in Vitro
MH  - Gestational Age
MH  - Gestational Sac/*anatomy & histology
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Reference Values
MH  - Retrospective Studies
MH  - Time Factors
MH  - Yolk Sac/*anatomy & histology
PMC - PMC7488996
OTO - NOTNLM
OT  - Crown-rump length
OT  - Embryonic heart rate
OT  - First trimester
OT  - Gestational sac
OT  - In vitro fertilization-embryo transfer
OT  - Reference interval
OT  - Yolk sac
COIS- The authors declare that they have no competing interests.
EDAT- 2020/09/16 06:00
MHDA- 2021/06/08 06:00
PMCR- 2020/09/14
CRDT- 2020/09/15 05:33
PHST- 2020/01/17 00:00 [received]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/09/15 05:33 [entrez]
PHST- 2020/09/16 06:00 [pubmed]
PHST- 2021/06/08 06:00 [medline]
PHST- 2020/09/14 00:00 [pmc-release]
AID - 10.1186/s12884-020-03186-2 [pii]
AID - 3186 [pii]
AID - 10.1186/s12884-020-03186-2 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2020 Sep 14;20(1):533. doi: 10.1186/s12884-020-03186-2.