PMID- 32928861
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 10
IP  - 9
DP  - 2020 Sep 14
TI  - Impact of infection in patients with non-ST elevation acute coronary syndrome 
      undergoing percutaneous coronary intervention: insight from a multicentre 
      observational cohort from China.
PG  - e038551
LID - 10.1136/bmjopen-2020-038551 [doi]
LID - e038551
AB  - OBJECTIVE: We aimed to describe the association between in-hospital infection and 
      prognosis among patients with non-ST elevation acute coronary syndrome (NSTE-ACS) 
      who received percutaneous coronary intervention (PCI). DESIGN: This observational 
      cohort originated from a database of patients with NSTE-ACS who underwent PCI 
      from 1 January 2010 to 31 December 2014. SETTING: Five centres in South China. 
      PARTICIPANTS: This multicentre observational cohort study consecutively included 
      8197 patients with NSTE-ACS who received PCI. Only patients with adequate 
      information to diagnose or rule out infection were included. Patients were 
      excluded if they were diagnosed with a malignant tumour, were pregnant or 
      presented with cardiogenic shock at the index date. Patients were grouped by 
      whether they had in-hospital infection or not. PRIMARY AND SECONDARY OUTCOME 
      MEASURES: The primary outcome was all-cause death and major bleeding during 
      hospitalisation. The secondary outcomes included all-cause death and major 
      bleeding during follow-up and in-hospital myocardial infarction. RESULTS: Of the 
      5215 patients, 206 (3.95%) acquired infection. Patients with infection had a 
      higher rate of in-hospital all-cause death and major bleeding (4.4% vs 0.2% and 
      16.5% vs 1.2%, respectively; p<0.001). After adjusting for confounders, infection 
      remained independently associated with in-hospital and long-term all-cause death 
      (OR, 13.19, 95% CI 4.59 to 37.87; HR, 2.03, 95% CI 1.52 to 2.71; p<0.001) and 
      major bleeding (OR, 10.24, 95% CI 6.17 to 16.98; HR, 5.31, 95% CI 3.49 to 8.08; 
      p<0.001). A subgroup analysis confirmed these results. CONCLUSIONS: The incidence 
      of infection is low during hospitalisation, but is associated with worse 
      in-hospital and long-term outcomes.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Chen, Peng-Yuan
AU  - Chen PY
AD  - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai 
      Hospital, the Second Hospital of Nanhai District Foshan City, Foshan, China.
FAU - Liu, Yuan-Hui
AU  - Liu YH
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
AD  - The Second School of Clinical Medicine, Guangdong Provincial People's Hospital, 
      Southern Medical University, Guangzhou, China.
FAU - Duan, Chong-Yang
AU  - Duan CY
AD  - Department of Biostatistics, School of Public Health, Southern Medical 
      University, Guangzhou, China.
FAU - Jiang, Lei
AU  - Jiang L
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
AD  - School of Medicine, Guangdong Provincial People's Hospital, South China 
      University of Technology, Guangzhou, China.
FAU - Wei, Xue-Biao
AU  - Wei XB
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Guo, Wei
AU  - Guo W
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Chen, Ji-Yan
AU  - Chen JY
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Tan, Ning
AU  - Tan N
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
AD  - The Second School of Clinical Medicine, Guangdong Provincial People's Hospital, 
      Southern Medical University, Guangzhou, China.
FAU - He, Peng-Cheng
AU  - He PC
AUID- ORCID: 0000-0001-7706-7105
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China gdhpc100@126.com.
AD  - The Second School of Clinical Medicine, Guangdong Provincial People's Hospital, 
      Southern Medical University, Guangzhou, China.
AD  - School of Medicine, Guangdong Provincial People's Hospital, South China 
      University of Technology, Guangzhou, China.
CN  - Pattern group and the members
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200914
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - *Acute Coronary Syndrome
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Humans
MH  - *Myocardial Infarction
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Treatment Outcome
PMC - PMC7490952
OTO - NOTNLM
OT  - cardiology
OT  - coronary heart disease
OT  - coronary intervention
COIS- Competing interests: None declared.
FIR - Chen, Ji-Yan
IR  - Chen JY
FIR - He, Peng-Cheng
IR  - He PC
FIR - Liu, Yuan-Hui
IR  - Liu YH
FIR - Wei, Xue-Biao
IR  - Wei XB
FIR - Jiang, Lei
IR  - Jiang L
FIR - Guo, Wei
IR  - Guo W
FIR - Zhou, Yin-Lin
IR  - Zhou YL
FIR - Chen, Zhu-Jun
IR  - Chen ZJ
FIR - Luo, Jian-Fang
IR  - Luo JF
FIR - Yu, Dan-Qing
IR  - Yu DQ
FIR - Geng, Qing-Shan
IR  - Geng QS
FIR - Tan, Ning
IR  - Tan N
FIR - Lin, Chun-Ying
IR  - Lin CY
FIR - Guo, Zhi-Qiang
IR  - Guo ZQ
FIR - Duan, Chong-Yang
IR  - Duan CY
FIR - Guo, Yan-Song
IR  - Guo YS
FIR - Chen, Wei
IR  - Chen W
FIR - Chen, Yi-Yue
IR  - Chen YY
FIR - Li, Jun
IR  - Li J
FIR - Li, Wen-Sheng
IR  - Li WS
EDAT- 2020/09/16 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/09/14
CRDT- 2020/09/15 05:41
PHST- 2020/09/15 05:41 [entrez]
PHST- 2020/09/16 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/14 00:00 [pmc-release]
AID - bmjopen-2020-038551 [pii]
AID - 10.1136/bmjopen-2020-038551 [doi]
PST - epublish
SO  - BMJ Open. 2020 Sep 14;10(9):e038551. doi: 10.1136/bmjopen-2020-038551.