PMID- 32930243
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210405
LR  - 20210405
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 12
IP  - 19
DP  - 2020 May 21
TI  - Derivatization and rapid GC-MS screening of chlorides relevant to the Chemical 
      Weapons Convention in organic liquid samples.
PG  - 2527-2535
LID - 10.1039/d0ay00263a [doi]
AB  - A simple derivatization technique was developed for the analysis of seven 
      Schedule 3 chemicals and one Schedule 2 chemical listed in the Chemical Weapons 
      Convention (CWC). Phosgene, phosphorus oxychloride, phosphorus trichloride, 
      phosphorus pentachloride, thionyl chloride, sulfur monochloride and sulfur 
      dichloride (Schedule 3) as well as arsenic trichloride (Schedule 2) were 
      derivatized using 1-propanol in 40% pyridine solution for analysis with gas 
      chromatography-mass spectrometry (GC-MS). Derivatization temperature and 
      concentration of the derivatization solution were optimized for maximum 
      derivatization recovery. The stabilities of the target analytes and their 
      derivatives in different solvents were studied. The derivatization yield showed a 
      linear response within the analyte concentration range of 0.1-2 mM (10-200 mug 
      ml-1) with correlation coefficients >0.99 (r2), except for AsCl3 which did not 
      show a linear response after derivatization. Good reproducibility with relative 
      standard deviations (RSDs) from 3 to 13% was achieved. The derivatization 
      recovery was 66% for phosgene and 67-80% for the P-containing chemicals 
      phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride. 
      Recommendations to use the method for screening the presence of these chemicals 
      in organic liquid samples are given. The method is used when CWC-related samples 
      are screened at VERIFIN.
FAU - Kuitunen, Marja-Leena
AU  - Kuitunen ML
AUID- ORCID: 0000-0002-1372-5575
AD  - VERIFIN, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 
      Helsinki, Finland. Marja-Leena.Kuitunen@alumni.helsinki.fi.
FAU - Altamirano, Jorgelina Cecilia
AU  - Altamirano JC
AUID- ORCID: 0000-0002-4022-3810
AD  - Laboratorio de Quimica Ambiental, Instituto Argentino de Nivologia, Glaciologia y 
      Ciencias Ambientales (IANIGLA, CCT-CONICET), Mendoza 5500, Argentina.
AD  - Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza, 
      Argentina.
FAU - Siegenthaler, Peter
AU  - Siegenthaler P
AD  - Federal Office for Civil Protection FOCP, Spiez Laboratory, Analytical Chemistry 
      Branch, CH-3700 Spiez, Switzerland.
FAU - Taure, Terhi Hannele
AU  - Taure TH
AD  - VERIFIN, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 
      Helsinki, Finland. Marja-Leena.Kuitunen@alumni.helsinki.fi.
FAU - Hakkinen, Vesa Antero
AU  - Hakkinen VA
AD  - VERIFIN, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 
      Helsinki, Finland. Marja-Leena.Kuitunen@alumni.helsinki.fi.
FAU - Vanninen, Paula Sinikka
AU  - Vanninen PS
AD  - VERIFIN, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 
      Helsinki, Finland. Marja-Leena.Kuitunen@alumni.helsinki.fi.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
SB  - IM
EDAT- 2020/09/16 06:00
MHDA- 2020/09/16 06:01
CRDT- 2020/09/15 08:53
PHST- 2020/09/15 08:53 [entrez]
PHST- 2020/09/16 06:00 [pubmed]
PHST- 2020/09/16 06:01 [medline]
AID - 10.1039/d0ay00263a [doi]
PST - ppublish
SO  - Anal Methods. 2020 May 21;12(19):2527-2535. doi: 10.1039/d0ay00263a.