PMID- 32930287
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 12
IP  - 20
DP  - 2020 May 28
TI  - Electrochemical determination of paracetamol in a pharmaceutical dose by 
      adsorptive voltammetry with a carbon paste/La(2)O(3) microcomposite.
PG  - 2608-2613
LID - 10.1039/d0ay00442a [doi]
AB  - This paper presents a new application for microcomposites based on carbon paste 
      (CP) and La2O3 (LaOX). This simple and versatile microcomposite (LaOX/CPE) was 
      applied toward the determination of paracetamol (PCM) through proton oxidation by 
      square wave adsorptive voltammetry (SWAdV). The anodic peak current for PCM 
      increased by nearly 70.0% compared with an unmodified CP, and the detection limit 
      was 0.020 mumol L-1. The relative standard deviations (RSDs) were 1.0% (n = 7). 
      The accuracy of the new method was evaluated with tap water spiked with known 
      quantities of PCM, while ascorbic acid, caffeine, and acetylsalicylic acid were 
      used for interference studies. Finally, the usefulness of the microcomposite was 
      shown to have acceptable results when applied to detect and quantify PCM in 
      various forms of a pharmaceutical dose, such as solid tablets, fruit-flavored 
      powders for colds and syrups for children.
FAU - Nagles, Edgar
AU  - Nagles E
AUID- ORCID: 0000-0002-2957-2817
AD  - Facultad de Quimica e Ing. Quimica, Universidad Nacional Mayor de San Marcos, 
      Lima, Peru. enaglesv@unmsm.edu.pe.
FAU - Ceroni, Mario
AU  - Ceroni M
AD  - Facultad de Quimica e Ing. Quimica, Universidad Nacional Mayor de San Marcos, 
      Lima, Peru. enaglesv@unmsm.edu.pe.
FAU - Hurtado-Murillo, John J
AU  - Hurtado-Murillo JJ
AD  - Departamento de Quimica, Universidad de los Andes, Carrera 1 No. 18A-12, Bogota, 
      Colombia.
FAU - Hurtado, John J
AU  - Hurtado JJ
AUID- ORCID: 0000-0002-0511-9719
AD  - Departamento de Quimica, Universidad de los Andes, Carrera 1 No. 18A-12, Bogota, 
      Colombia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
RN  - 0 (Oxides)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 4QI5EL790W (lanthanum oxide)
RN  - 6I3K30563S (Lanthanum)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - *Acetaminophen
MH  - *Carbon
MH  - Child
MH  - Electrodes
MH  - Humans
MH  - Lanthanum
MH  - Oxides
EDAT- 2020/09/16 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/15 08:53
PHST- 2020/09/15 08:53 [entrez]
PHST- 2020/09/16 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - 10.1039/d0ay00442a [doi]
PST - ppublish
SO  - Anal Methods. 2020 May 28;12(20):2608-2613. doi: 10.1039/d0ay00442a.