PMID- 32932412 OWN - NLM STAT- MEDLINE DCOM- 20210407 LR - 20220107 IS - 1944-7884 (Electronic) IS - 1525-4135 (Print) IS - 1525-4135 (Linking) VI - 85 IP - 5 DP - 2020 Dec 15 TI - Cognitive and Neuronal Link With Inflammation: A Longitudinal Study in People With and Without HIV Infection. PG - 617-625 LID - 10.1097/QAI.0000000000002484 [doi] AB - BACKGROUND: Across many settings, lack of virologic control remains common in people with HIV (PWH) because of late presentation and lack of retention in care. This contributes to neuronal damage and neurocognitive impairment, which remains prevalent. More evidence is needed to understand these outcomes in both PWH and people without HIV (PWOH). METHODS: We recruited PWH initiating antiretroviral therapy and PWOH at 2 sites in the United States. One hundred eight adults were enrolled (56 PWOH and 52 PWH), most of whom had a second assessment at least 24 weeks later (193 total assessments). Tumor necrosis factor alpha, monocyte chemotactic protein-1 (MCP-1), neopterin, soluble CD14, and neurofilament light chain protein (NFL) were measured in plasma and cerebrospinal fluid (CSF). Using multivariate models including Bayesian model averaging, we analyzed factors associated with global neuropsychological performance (NPT-9) and CSF NFL at baseline and over time. RESULTS: At baseline, higher CSF MCP-1 and plasma sCD14 were associated with worse NPT-9 in PWH, while CSF HIV RNA decrease was the only marker associated with improved NPT-9 over time. Among PWH, higher CSF neopterin was most closely associated with higher NFL. Among PWOH, higher CSF MCP-1 was most closely associated with higher NFL. After antiretroviral therapy initiation, decrease in CSF MCP-1 was most closely associated with NFL decrease. CONCLUSION: Monocyte-associated CSF biomarkers are highly associated with neuronal damage in both PWH and PWOH. More research is needed to evaluate whether therapies targeting monocyte-associated inflammation may ameliorate HIV-associated neurobehavioral diseases. FAU - Anderson, Albert M AU - Anderson AM AD - Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA. FAU - Jang, Jeong Hoon AU - Jang JH AD - Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN. FAU - Easley, Kirk A AU - Easley KA AD - Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA. FAU - Fuchs, Dietmar AU - Fuchs D AD - Division of Biological Chemistry, Innsbruck Medical University, Innsbruck, Austria. FAU - Gisslen, Magnus AU - Gisslen M AD - Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Infectious Diseases, Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden. FAU - Zetterberg, Henrik AU - Zetterberg H AD - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden. AD - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden. AD - Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, United Kingdom. AD - UK Dementia Research Institute at UCL, London, United Kingdom. FAU - Blennow, Kaj AU - Blennow K AD - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden. AD - Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden. FAU - Ellis, Ronald J AU - Ellis RJ AD - Psychiatry, and. AD - Medicine, University of California, San Diego, San Diego, CA. FAU - Franklin, Donald AU - Franklin D AD - Psychiatry, and. FAU - Heaton, Robert K AU - Heaton RK AD - Psychiatry, and. FAU - Grant, Igor AU - Grant I AD - Psychiatry, and. FAU - Letendre, Scott L AU - Letendre SL AD - Psychiatry, and. AD - Medicine, University of California, San Diego, San Diego, CA. LA - eng GR - K24 MH097673/MH/NIMH NIH HHS/United States GR - R01 MH058076/MH/NIMH NIH HHS/United States GR - R21 MH118092/MH/NIMH NIH HHS/United States GR - R01 AG062387/AG/NIA NIH HHS/United States GR - P30 MH062512/MH/NIMH NIH HHS/United States GR - R01 MH107345/MH/NIMH NIH HHS/United States GR - K23 MH095679/MH/NIMH NIH HHS/United States GR - P30 AI050409/AI/NIAID NIH HHS/United States GR - R21 MH085610/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - J Acquir Immune Defic Syndr JT - Journal of acquired immune deficiency syndromes (1999) JID - 100892005 RN - 0 (Biomarkers) RN - 0 (Neurofilament Proteins) SB - IM MH - Adult MH - Biomarkers/blood/cerebrospinal fluid MH - Case-Control Studies MH - Female MH - HIV Infections/blood/cerebrospinal fluid/*complications MH - Humans MH - Inflammation/blood/cerebrospinal fluid/*etiology MH - Longitudinal Studies MH - Male MH - Neurocognitive Disorders/*etiology MH - Neurofilament Proteins/blood/cerebrospinal fluid MH - Neuropsychological Tests PMC - PMC8725606 MID - NIHMS1757821 COIS- Conflicts of interest A Anderson reports no conflicts J Jang reports no conflicts K Easley reports no conflicts D Fuchs reports no conflicts M Gisslen reports no conflicts H Zetterberg reports no conflicts R Ellis reports no conflicts D Franklin reports no conflicts R Heaton reports no conflicts I Grant reports no conflicts S Letendre reports no conflicts EDAT- 2020/09/16 06:00 MHDA- 2021/04/10 06:00 PMCR- 2022/01/04 CRDT- 2020/09/15 20:24 PHST- 2020/09/16 06:00 [pubmed] PHST- 2021/04/10 06:00 [medline] PHST- 2020/09/15 20:24 [entrez] PHST- 2022/01/04 00:00 [pmc-release] AID - 00126334-202012150-00016 [pii] AID - 10.1097/QAI.0000000000002484 [doi] PST - ppublish SO - J Acquir Immune Defic Syndr. 2020 Dec 15;85(5):617-625. doi: 10.1097/QAI.0000000000002484.