PMID- 32932584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 9
DP  - 2020 Sep 12
TI  - Hyperhomocysteinemia Induced by Methionine Excess Is Effectively Suppressed by 
      Betaine in Geese.
LID - 10.3390/ani10091642 [doi]
LID - 1642
AB  - The objective of our study was to investigate the effects of excess Methionine 
      (Met) on the growth performance, serum homocysteine levels, apoptotic rates, and 
      Bax and Bcl-2 protein levels in geese and to study the role of Bet (betaine) in 
      relieving excess Met-induced hyperhomocysteinemia (HHcy). In this study, 150 
      healthy male 14-day-old Yangzhou geese of similar body weight were randomly 
      distributed into three groups with five replicates per treatment and 10 geese per 
      replicate: the control group (fed a control diet), the Met toxicity group (fed 
      the control diet +1% Met), and the Bet detoxification group (fed the control diet 
      +1% Met +0.2% Bet). At 28, 49, and 70 d of age, the geese in the Met toxicity 
      group had significantly lower body weights than those in the control group (p < 
      0.05). The serum homocysteine levels in geese at 70 d of age in the 
      detoxification group were significantly lower than those in the Met toxicity 
      group (p < 0.05). Compared with the control, Met significantly increased 
      cardiomyocyte apoptosis rates, while Bet reduced them. In conclusion, our results 
      suggest that excess methionine reduces body weight induced by myocardial 
      apoptosis, and Bet can be used to effectively lower plasma homocysteine levels.
FAU - Yang, Zhi
AU  - Yang Z
AD  - Joint International Research Laboratory of Agriculture and Agri-Product Safety of 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu 
      Province, China.
FAU - Yang, Yu
AU  - Yang Y
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      Jiangsu Province, China.
FAU - Yang, Jinjin
AU  - Yang J
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      Jiangsu Province, China.
FAU - Wan, Xiaoli
AU  - Wan X
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      Jiangsu Province, China.
FAU - Yang, Haiming
AU  - Yang H
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      Jiangsu Province, China.
FAU - Wang, Zhiyue
AU  - Wang Z
AD  - Joint International Research Laboratory of Agriculture and Agri-Product Safety of 
      the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu 
      Province, China.
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, 
      Jiangsu Province, China.
LA  - eng
GR  - (Grant No. BK20190897)/Project of the Natural Science Foundation of Jiangsu 
      Province/
GR  - (Grant No. SZR2019000031)/Natural Science Foundation of Yangzhou City/
GR  - (CARS-42-11)/China Agriculture Research System/
PT  - Journal Article
DEP - 20200912
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7552138
OTO - NOTNLM
OT  - betaine
OT  - geese
OT  - hyperhomocysteinemia
OT  - methionine excess
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/17 06:00
MHDA- 2020/09/17 06:01
PMCR- 2020/09/12
CRDT- 2020/09/16 01:00
PHST- 2020/08/03 00:00 [received]
PHST- 2020/09/06 00:00 [revised]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/09/16 01:00 [entrez]
PHST- 2020/09/17 06:00 [pubmed]
PHST- 2020/09/17 06:01 [medline]
PHST- 2020/09/12 00:00 [pmc-release]
AID - ani10091642 [pii]
AID - animals-10-01642 [pii]
AID - 10.3390/ani10091642 [doi]
PST - epublish
SO  - Animals (Basel). 2020 Sep 12;10(9):1642. doi: 10.3390/ani10091642.