PMID- 32932637
OWN - NLM
STAT- MEDLINE
DCOM- 20210406
LR  - 20210406
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 18
DP  - 2020 Sep 12
TI  - Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by 
      Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-kappaB.
LID - 10.3390/molecules25184178 [doi]
LID - 4178
AB  - Mast cells are effector cells that initiate allergic inflammatory immune 
      responses by inducing inflammatory mediators. Boehmeria nivea (Linn.) Gaudich is 
      a natural herb in the nettle family Urticaceae that possesses numerous 
      pharmacological properties. Despite the various pharmacological benefits of 
      Boehmeria nivea, its effects on allergic inflammation have not yet been 
      determined. Here, we investigated the effect of the ethanol extract of Boehmeria 
      nivea (BNE) on degranulation rat basophilic leukemia (RBL)-2H3 mast cells 
      stimulated with anti-dinitrophenyl (anti-DNP) and bovine serum albumin (BSA) 
      during immunoglobulin E (IgE)-mediated allergic immune response. The results 
      showed inhibition of the release of beta-hexosaminidase and histamine from the 
      cells. BNE suppressed pro-inflammatory cytokines (Tumor necrosis factor (TNF)-alpha, 
      Interleukin (IL)-1beta, and IL-6) and reduced T helper (Th)2 cytokine IL-4 
      expression and/or secretion correlated with the downregulation of p38, 
      extracellular signal-regulated kinases (ERK) mitogen-activated protein kinase 
      (MAPK), and nuclear factor-kappaB (NF-kappaB) signaling pathways in treated RBL-2H3 mast 
      cells. In passive cutaneous anaphylaxis, treatment with BNE during IgE-mediated 
      local allergic reaction triggered a reduction in mouse ear pigmentation and 
      thickness. Taken together, these results indicated that BNE suppressed mast 
      cell-mediated inflammation, suggesting that BNE might be a candidate for the 
      treatment of various allergic disorders.
FAU - Lim, Ji-Ye
AU  - Lim JY
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea.
FAU - Lee, Ji-Hyun
AU  - Lee JH
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea.
FAU - Lee, Bo-Ri
AU  - Lee BR
AD  - Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental 
      Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea.
FAU - Kim, Mi Ae
AU  - Kim MA
AD  - Department of Third Medicine, Professional Graduate School of Korean Medicine, 
      Wonkwang University, Iksan, Jeonbuk 54538, Korea.
FAU - Lee, Young-Mi
AU  - Lee YM
AD  - Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental 
      Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea.
FAU - Kim, Dae-Ki
AU  - Kim DK
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea.
FAU - Choi, Jin Kyeong
AU  - Choi JK
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea.
LA  - eng
GR  - NRF-2019R1F1A1061198/National Research Foundation of Korea funded by the Ministry 
      of Education, Science and Technology/
PT  - Journal Article
DEP - 20200912
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Anaphylaxis/metabolism
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology
MH  - Boehmeria/*chemistry
MH  - Cell Line, Tumor
MH  - Cytokines/metabolism
MH  - Histamine/chemistry
MH  - Histamine Release/drug effects
MH  - Hypersensitivity/*drug therapy
MH  - Immunoglobulin E/chemistry
MH  - Inflammation/*drug therapy
MH  - Inflammation Mediators/metabolism
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Mast Cells/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/*drug effects
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Pigmentation
MH  - Plant Extracts/*pharmacology
MH  - Plant Leaves/chemistry
MH  - Rats
MH  - Serum Albumin, Bovine/chemistry
MH  - beta-N-Acetylhexosaminidases/chemistry
PMC - PMC7570717
OTO - NOTNLM
OT  - Boehmeria nivea
OT  - allergic inflammation
OT  - cytokines
OT  - immunoglobulin E
OT  - mast cells
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/17 06:00
MHDA- 2021/04/07 06:00
PMCR- 2020/09/12
CRDT- 2020/09/16 01:00
PHST- 2020/08/25 00:00 [received]
PHST- 2020/09/08 00:00 [revised]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/09/16 01:00 [entrez]
PHST- 2020/09/17 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2020/09/12 00:00 [pmc-release]
AID - molecules25184178 [pii]
AID - molecules-25-04178 [pii]
AID - 10.3390/molecules25184178 [doi]
PST - epublish
SO  - Molecules. 2020 Sep 12;25(18):4178. doi: 10.3390/molecules25184178.