PMID- 32933402
OWN - NLM
STAT- MEDLINE
DCOM- 20210302
LR  - 20210302
IS  - 0301-1526 (Print)
IS  - 0301-1526 (Linking)
VI  - 50
IP  - 2
DP  - 2021 Feb
TI  - Relationship between total plasma homocysteine and the risk of aneurysms - a 
      meta-analysis.
PG  - 110-115
LID - 10.1024/0301-1526/a000891 [doi]
AB  - Our meta-analysis focused on the relationship between homocysteine (Hcy) level 
      and the incidence of aneurysms and looked at the relationship between smoking, 
      hypertension and aneurysms. A systematic literature search of Pubmed, Web of 
      Science, and Embase databases (up to March 31, 2020) resulted in the 
      identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy 
      participants. Combined analysis of the included studies showed that number of 
      smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was 
      higher than that in the control groups, and the total plasma Hcy level in 
      aneurysm patients was also higher. These findings suggest that smoking, 
      hypertension and HHcy may be risk factors for the development and progression of 
      aneurysms. Although the heterogeneity of meta-analysis was significant, it was 
      found that the heterogeneity might come from the difference between race and 
      disease species through subgroup analysis. Large-scale randomized controlled 
      studies of single species and single disease species are needed in the future to 
      supplement the accuracy of the results.
FAU - Zhang, Hanji
AU  - Zhang H
AD  - Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, 
      Changchun City, Jilin Province, China.
FAU - Yin, Dexin
AU  - Yin D
AD  - Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, 
      Changchun City, Jilin Province, China.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, 
      Changchun City, Jilin Province, China.
FAU - Li, Yezhou
AU  - Li Y
AD  - Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, 
      Changchun City, Jilin Province, China.
FAU - Yao, Dejiang
AU  - Yao D
AD  - Department of Chinese medicine, Third department of surgery, The Center Hospital 
      of Enshi Tujia and Miao Autonomous Prefecture, Wuhan University, Enshi City, 
      Hubei Province, China.
FAU - Sun, Dajun
AU  - Sun D
AD  - Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, 
      Changchun City, Jilin Province, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200916
PL  - Switzerland
TA  - Vasa
JT  - VASA. Zeitschrift fur Gefasskrankheiten
JID - 0317051
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - *Aneurysm
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia/diagnosis/epidemiology
MH  - *Hypertension
MH  - Plasma
OTO - NOTNLM
OT  - aneurysms
OT  - homocysteine (Hcy) level
OT  - hyperhomocysteinemia (HHcy)
OT  - hypertension
OT  - meta-analysis
OT  - smoking
EDAT- 2020/09/17 06:00
MHDA- 2021/03/03 06:00
CRDT- 2020/09/16 05:27
PHST- 2020/09/17 06:00 [pubmed]
PHST- 2021/03/03 06:00 [medline]
PHST- 2020/09/16 05:27 [entrez]
AID - 10.1024/0301-1526/a000891 [doi]
PST - ppublish
SO  - Vasa. 2021 Feb;50(2):110-115. doi: 10.1024/0301-1526/a000891. Epub 2020 Sep 16.