PMID- 32936994
OWN - NLM
STAT- MEDLINE
DCOM- 20210714
LR  - 20210714
IS  - 1552-6569 (Electronic)
IS  - 1051-2284 (Linking)
VI  - 31
IP  - 1
DP  - 2021 Jan
TI  - Cognitive Decline and White Matter Integrity Degradation in Myotonic Dystrophy 
      Type I.
PG  - 192-198
LID - 10.1111/jon.12786 [doi]
AB  - BACKGROUND AND PURPOSE: Myotonic Dystrophy Type I (DM1) is a neurodegenerative, 
      genetic, and multisystemic disorder with a large variety of symptoms due to a CTG 
      trinucleotide expansion located on Dystrophia Myotonica Protein Kinase (DMPK) 
      gene. Previous reports have shown cognitive deterioration in these patients. 
      Given that white matter (WM) degradation has also been reported in DM1 patients, 
      here we explored if alterations in the cognitive profile of DM1 patients could be 
      related to the deterioration of WM. METHODS: A total of 22 classic DM1 patients 
      with age range (18-56 years) and 22 matched healthy control subjects were 
      neuropsychological evaluated by the Cambridge Neuropsychological Test Automated 
      (CANTAB). Patients were evaluated with the Muscular Impairment Rating Scale 
      (MIRS). We then evaluated the cerebral WM integrity using the Fractional 
      Anisotropy (FA) index obtained from the Diffusion Tensor Imaging (DTI) data 
      acquired with a 3T MR scanner. RESULTS: DM1 patients showed generalized reduction 
      of WM integrity across the brain. Similarly, patients' neuropsychological 
      evaluation showed significant deficits in memory and problem-solving tasks. 
      Correlation analyses showed a significant correlation between FA deterioration at 
      frontal, temporomedial, and parietal lobes and delayed matched to sample 
      deficits. CONCLUSIONS: Our results suggest that despite the pervasive WM 
      integrity loss in DM1 disorder, specific memory impairments can be associated to 
      discreet areas of WM deterioration in these patients.
CI  - (c) 2020 American Society of Neuroimaging.
FAU - Lopez-Titla, Maria Margarita
AU  - Lopez-Titla MM
AUID- ORCID: 0000-0001-9359-0772
AD  - Instituto de Neuroetologia, Universidad Veracruzana, Xalapa, 91190, Mexico.
FAU - Chirino, Amanda
AU  - Chirino A
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico, Ciudad de Mexico, 04510, Mexico.
FAU - Cruz Solis, Sara Vanessa
AU  - Cruz Solis SV
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico, Ciudad de Mexico, 04510, Mexico.
FAU - Hernandez-Castillo, Carlos R
AU  - Hernandez-Castillo CR
AUID- ORCID: 0000-0003-1208-5577
AD  - CONACYT-Instituto de Neuroetologia, Universidad Veracruzana, Xalapa, 91190, 
      Mexico.
FAU - Diaz, Rosalinda
AU  - Diaz R
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico, Ciudad de Mexico, 04510, Mexico.
FAU - Marquez-Quiroz, Luz Del Carmen
AU  - Marquez-Quiroz LDC
AD  - Laboratorio de Medicina Genomica, Departamento de Genetica (CENIAQ), Instituto 
      Nacional de Rehabilitacion-Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de 
      Mexico, 14389, Mexico.
FAU - Magana, Jonathan J
AU  - Magana JJ
AUID- ORCID: 0000-0003-4399-4618
AD  - Laboratorio de Medicina Genomica, Departamento de Genetica (CENIAQ), Instituto 
      Nacional de Rehabilitacion-Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de 
      Mexico, 14389, Mexico.
AD  - Escuela de Ingenieria, Departamento de Biotecnologia, Instituto Tecnologico y de 
      Estudios Superiores de Monterrey-Campus, Ciudad de Mexico, 14380, Mexico.
FAU - Beltran-Parrazal, Luis
AU  - Beltran-Parrazal L
AUID- ORCID: 0000-0002-4765-9051
AD  - Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, 91190, 
      Mexico.
FAU - Fernandez-Ruiz, Juan
AU  - Fernandez-Ruiz J
AUID- ORCID: 0000-0002-4038-0904
AD  - Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico, Ciudad de Mexico, 04510, Mexico.
AD  - Facultad de Psicologia, Universidad Veracruzana, Xalapa, 91700, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200916
PL  - United States
TA  - J Neuroimaging
JT  - Journal of neuroimaging : official journal of the American Society of 
      Neuroimaging
JID - 9102705
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anisotropy
MH  - Cognitive Dysfunction/*complications
MH  - Diffusion Tensor Imaging
MH  - Humans
MH  - Male
MH  - Memory
MH  - Middle Aged
MH  - Myotonic Dystrophy/complications/diagnostic imaging/*pathology/*physiopathology
MH  - Neuropsychological Tests
MH  - White Matter/diagnostic imaging/*pathology/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - CANTAB
OT  - DM1
OT  - DTI
OT  - MRI
OT  - memory
EDAT- 2020/09/17 06:00
MHDA- 2021/07/15 06:00
CRDT- 2020/09/16 17:13
PHST- 2020/07/02 00:00 [received]
PHST- 2020/08/29 00:00 [accepted]
PHST- 2020/09/17 06:00 [pubmed]
PHST- 2021/07/15 06:00 [medline]
PHST- 2020/09/16 17:13 [entrez]
AID - 10.1111/jon.12786 [doi]
PST - ppublish
SO  - J Neuroimaging. 2021 Jan;31(1):192-198. doi: 10.1111/jon.12786. Epub 2020 Sep 16.