PMID- 32937623
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20210128
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 181
IP  - 12
DP  - 2020
TI  - Risk Factors for Safety of Allergen-Specific Sublingual Immunotherapy in Children 
      with Allergic Rhinitis.
PG  - 934-940
LID - 10.1159/000508523 [doi]
AB  - A good compliance often attributes to good efficacy and safety of sublingual 
      immunotherapy (SLIT). However, few studies have been conducted on the safety of 
      SLIT treatment in children. We aimed to confirm the pretreatment parameters to 
      predict the safety in children who underwent SLIT. 601 children with allergic 
      rhinitis (AR) treated with SLIT were enrolled in this study. Baseline clinical 
      information and laboratory parameters were collected. The clinical response and 
      adverse events (AEs) were recorded and evaluated. A multivariate logistic 
      regression model was established to confirm the predictors for AEs. The AEs were 
      reported in 75 children (13.8%). The serum-specific IgE (s-IgE) level was 
      significantly correlated with the occurrence of AEs by multivariate logistic 
      regression analysis. Our receiver operating characteristic (ROC) analysis of the 
      serum s-IgE levels >21.6 IU/mL had the best sensitivity (83.7%) and specificity 
      (76.7%) to predict safety. The serum s-IgE level was significantly correlated 
      with safety of SLIT in children, which may be helpful for patient selection 
      before SLIT.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Liu, Wenlong
AU  - Liu W
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China, lwl20103@163.com.
FAU - Zeng, Qingxiang
AU  - Zeng Q
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China.
FAU - Yan, Shengbao
AU  - Yan S
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China.
FAU - Sun, Changzhi
AU  - Sun C
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China.
FAU - Tang, Yiquan
AU  - Tang Y
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China.
FAU - Luo, Renzhong
AU  - Luo R
AD  - Department of Otolaryngology, Guangzhou Medical University, Guangzhou Women and 
      Children's Medical Center, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200916
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Child
MH  - Drug-Related Side Effects and Adverse Reactions/diagnosis/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Logistic Models
MH  - Male
MH  - Patient Compliance
MH  - Prognosis
MH  - ROC Curve
MH  - Rhinitis, Allergic/diagnosis/*epidemiology/therapy
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Sublingual Immunotherapy/adverse effects/*methods
OTO - NOTNLM
OT  - Adverse events
OT  - Allergic rhinitis
OT  - Efficacy
OT  - Safety
OT  - Sublingual immunotherapy
EDAT- 2020/09/17 06:00
MHDA- 2021/01/29 06:00
CRDT- 2020/09/16 20:13
PHST- 2020/03/30 00:00 [received]
PHST- 2020/05/06 00:00 [accepted]
PHST- 2020/09/17 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/09/16 20:13 [entrez]
AID - 000508523 [pii]
AID - 10.1159/000508523 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2020;181(12):934-940. doi: 10.1159/000508523. Epub 2020 
      Sep 16.