PMID- 32938820
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201009
IS  - 2211-9132 (Print)
IS  - 2211-9140 (Electronic)
IS  - 2211-9132 (Linking)
VI  - 39
IP  - 3
DP  - 2020 Sep 30
TI  - Sodium-glucose cotransporter-2 inhibitor for renal function preservation in 
      patients with type 2 diabetes mellitus: A Korean Diabetes Association and Korean 
      Society of Nephrology consensus statement.
PG  - 269-283
LID - 10.23876/j.krcp.20.132 [doi]
AB  - Diabetes is a leading cause of end-stage renal disease. Therefore, prevention of 
      renal dysfunction is an important treatment goal in the management of diabetes. 
      The data of landmark cardiovascular outcome trials of sodiumglucose 
      cotransporter-2 (SGLT2) inhibitors showed profound reno-protective effects. The 
      Korean Diabetes Association and the Korean Society of Nephrology reviewed 
      clinical trials and performed a meta-analysis to assess the effects of SGLT2 
      inhibitors on the preservation of estimated glomerular filtration rate (eGFR). We 
      limited the data of SGLT2 inhibitors which can be prescribed in Korea. Both eGFR 
      value and its change from the baseline were significantly more preserved in the 
      SGLT2-inhibitor treatment group compared to the control group after 156 weeks. 
      However, some known adverse events were increased in SGLT2 inhibitor treatment, 
      such as genital infection, diabetic ketoacidosis, and volume depletion. We 
      recommend long-term use of SGLT2 inhibitors in patients with type 2 diabetes 
      mellitus (T2DM) for attenuation of renal function decline. However, we cannot 
      generalize our recommendations due to the lack of long-term clinical trials 
      testing the reno-protective effects of every SGLT2 inhibitor in a broad range of 
      patients with T2DM. This recommendation can be revised and updated after the 
      publication of several large-scale renal outcome trials.
FAU - Oh, Tae Jung
AU  - Oh TJ
AUID- ORCID: 0000-0002-5078-6123
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seongnam, Republic of Korea.
FAU - Moon, Ju-Young
AU  - Moon JY
AUID- ORCID: 0000-0003-3244-8371
AD  - Division of Nephrology, Department of Internal Medicine, Kyung Hee University 
      School of Medicine, Seoul, Republic of Korea.
FAU - Hur, Kyu Yeon
AU  - Hur KY
AUID- ORCID: 0000-0002-3065-7252
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Ko, Seung Hyun
AU  - Ko SH
AUID- ORCID: 0000-0003-3703-1479
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, St. 
      Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, 
      Republic of Korea.
FAU - Kim, Hyun Jung
AU  - Kim HJ
AUID- ORCID: 0000-0002-9520-1109
AD  - Department of Preventive Medicine, Korea University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Taehee
AU  - Kim T
AUID- ORCID: 0000-0002-3001-234X
AD  - Division of Nephrology, Department of Internal Medicine, Inje University Busan 
      Paik Hospital, Inje University School of Medicine, Busan, Republic of Korea.
FAU - Lee, Dong Won
AU  - Lee DW
AUID- ORCID: 0000-0003-0282-484X
AD  - Division of Nephrology, Department of Internal Medicine, Pusan National 
      University School of Medicine, Yangsan, Republic of Korea.
FAU - Moon, Min Kyong
AU  - Moon MK
AUID- ORCID: 0000-0002-5460-2846
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Seoul Metropolitan Government Seoul National 
      University Boramae Medical Center, Seoul, Republic of Korea.
CN  - Committee of Clinical Practice Guideline, Korean Diabetes Association and 
      Committee of the Cooperative Studies, Korean Society of Nephrology
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Kidney Res Clin Pract
JT  - Kidney research and clinical practice
JID - 101586778
PMC - PMC7530358
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Glomerular filtration rate
OT  - Renal function
OT  - Sodium-glucose transporter-2 inhibitors
OT  - type 2
COIS- Conflicts of interest All authors have no conflicts of interest to declare.
EDAT- 2020/09/18 06:00
MHDA- 2020/09/18 06:01
PMCR- 2020/09/30
CRDT- 2020/09/17 05:38
PHST- 2020/07/21 00:00 [received]
PHST- 2020/08/07 00:00 [revised]
PHST- 2020/08/09 00:00 [accepted]
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2020/09/18 06:01 [medline]
PHST- 2020/09/17 05:38 [entrez]
PHST- 2020/09/30 00:00 [pmc-release]
AID - j.krcp.20.132 [pii]
AID - KRCP-39-269 [pii]
AID - 10.23876/j.krcp.20.132 [doi]
PST - ppublish
SO  - Kidney Res Clin Pract. 2020 Sep 30;39(3):269-283. doi: 10.23876/j.krcp.20.132.