PMID- 32939244
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2045-3701 (Print)
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 10
DP  - 2020
TI  - Biological properties of bone marrow stem cells and adipose-derived stem cells 
      derived from T2DM rats: a comparative study.
PG  - 102
LID - 10.1186/s13578-020-00465-5 [doi]
LID - 102
AB  - BACKGROUND: Patients with type 2 diabetes mellitus (T2DM), especially those with 
      poor glycemic control, are characterized by low bone mass and destruction of bone 
      microstructure. Nowadays, autologous mesenchymal stem cells (auto-MSCs) have been 
      used to repair defects and promote tissue regeneration due to handy source, low 
      immunogenicity and self-renewing and multi-differentiating potential. However, 
      T2DM changed the biological properties of auto-MSCs, and investigating the most 
      suitable auto-MSCs for T2DM patients becomes a focus in tissue engineering. 
      RESULTS: In this research, we compared the biological characteristics of 
      adipose-derived stem cells (ASCs) and bone marrow stem cells (BMSCs) derived from 
      T2DM rats. These results demonstrated that ASCs had a higher proliferation rate, 
      colony-formation and cell-sheet forming ability, while BMSCs got better 
      osteogenesis-related staining, expression of osteogenesis-related genes and 
      proteins, and osteogenic capacity in vitro. CONCLUSIONS: As it turned out, 
      ASCs from T2DM had a higher proliferation, while BMSCs had significantly higher 
      osteogenetic ability no matter in vitro and in vivo. Therefore, we should take 
      into account the specific and dominated properties of MSC according to different 
      needs to optimize the protocols and improve clinical outcomes for tissue 
      regeneration of T2DM patients.
CI  - (c) The Author(s) 2020.
FAU - Wang, Lei
AU  - Wang L
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, 98 XiWu Road, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
AD  - Clinical Research Center of Shaanxi Province for Dental and Maxillofacial 
      Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
FAU - Shi, Shaojie
AU  - Shi S
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and 
      Advanced Manufacture, School of Stomatology, Air Force Medical University, Xi'an, 
      Shaanxi People's Republic of China. GRID: grid.233520.5. ISNI: 0000 0004 1761 
      4404
FAU - Bai, Ruiping
AU  - Bai R
AD  - Department of Math and Physics, School of Basic Medicine, Air Force Medical 
      University, Xi'an, 710032 Shaanxi People's Republic of China. GRID: 
      grid.233520.5. ISNI: 0000 0004 1761 4404
FAU - Wang, Yue
AU  - Wang Y
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, 98 XiWu Road, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
AD  - Clinical Research Center of Shaanxi Province for Dental and Maxillofacial 
      Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
FAU - Guo, Zhao
AU  - Guo Z
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, 98 XiWu Road, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
AD  - Clinical Research Center of Shaanxi Province for Dental and Maxillofacial 
      Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004 
      Shaanxi People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 
      1243
FAU - Li, Doudou
AU  - Li D
AD  - State Key Laboratory of Military Stomatology & National Clinical Research Center 
      for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and 
      Advanced Manufacture, School of Stomatology, Air Force Medical University, Xi'an, 
      Shaanxi People's Republic of China. GRID: grid.233520.5. ISNI: 0000 0004 1761 
      4404
LA  - eng
PT  - Journal Article
DEP - 20200907
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC7487578
OTO - NOTNLM
OT  - Cell proliferation
OT  - Cell sheets
OT  - Mesenchymal stem cells
OT  - Osteogenic induction
OT  - Type 2 diabetes mellitus
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2020/09/18 06:00
MHDA- 2020/09/18 06:01
PMCR- 2020/09/07
CRDT- 2020/09/17 05:44
PHST- 2019/11/28 00:00 [received]
PHST- 2020/08/27 00:00 [accepted]
PHST- 2020/09/17 05:44 [entrez]
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2020/09/18 06:01 [medline]
PHST- 2020/09/07 00:00 [pmc-release]
AID - 465 [pii]
AID - 10.1186/s13578-020-00465-5 [doi]
PST - epublish
SO  - Cell Biosci. 2020 Sep 7;10:102. doi: 10.1186/s13578-020-00465-5. eCollection 
      2020.