PMID- 32939513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2699-9404 (Electronic)
IS  - 2699-9404 (Linking)
VI  - 7
IP  - 2
DP  - 2020 Aug
TI  - Utility of KRAS Gene and Clinicopathological Features in the Assessment of the 
      Risk of Type 2 Diabetes in the Etiology of Colon Cancer.
PG  - 35-40
LID - 10.1055/s-0040-1714415 [doi]
AB  - Background  Cancer and diabetes have a tremendous impact on health globally. This 
      study aimed to evaluate the KRAS gene in colon cancer tissues obtained from 
      patients with type 2 diabetes mellitus (T2DM). Materials and Methods  Data from 
      315 cases (156 colon diabetics and 159 patients were nondiabetics) were 
      retrospectively retrieved. mRNA from surgically resected colon cancer tumors were 
      also retrieved. Results  The expression of KRAS mRNA was significantly higher in 
      patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were 
      significantly amplified from primary to metastatic lesions ( p  < 0.001). 
      Conclusion  The association between T2DM and colon cancer was well-established in 
      the present study.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution License, permitting unrestricted use, 
      distribution, and reproduction so long as the original work is properly cited. ( 
      https://creativecommons.org/licenses/by/4.0/ ).
FAU - Al-Qahtani, Wedad Saeed
AU  - Al-Qahtani WS
AD  - Department of Forensic Sciences, Naif Arab University for Security Sciences, 
      Riyadh, Saudi Arabia.
FAU - Al-Olayan, Ebtesam
AU  - Al-Olayan E
AD  - Department of Zoology, College of Science, King Saud University Riyadh, Riyadh, 
      Saudi Arabia.
FAU - Albani, Fatimah Gh
AU  - Albani FG
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Suliman, Rania Saad
AU  - Suliman RS
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Aljarba, Nada Hamad
AU  - Aljarba NH
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Al-Humaidhi, E M
AU  - Al-Humaidhi EM
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Almurshedi, Alanood S
AU  - Almurshedi AS
AD  - Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Domiaty, Dalia Mostafa
AU  - Domiaty DM
AD  - Department of Biology, College of Science, Jeddah University, Jeddah, Saudi 
      Arabia.
FAU - Alduwish, Manal Abdullah
AU  - Alduwish MA
AD  - Department of Biology, Prince Sattam bin Abdulaziz University, College of Science 
      and Humanities, Alkarj, Saudi Arabia.
FAU - Al-Otaibi, Aljohara M
AU  - Al-Otaibi AM
AD  - Department of Biology, College of Science, Princess Nourah bint Abdulrahman 
      University, Riyadh, Saudi Arabia.
FAU - Elasbali, Abdelbaset Mohamed
AU  - Elasbali AM
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Jouf University, Qurayyat, Saudi Arabia.
FAU - Ahmed, Hussain Gadelkarim
AU  - Ahmed HG
AD  - College of Medicine, University of Hail, Hail, Saudi Arabia.
AD  - Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, 
      Hail, Saudi Arabia.
AD  - Department of Histopathology and Cytology, CMLS, University of Khartoum, Sudan.
FAU - Almutlaq, Bassam Ahmed
AU  - Almutlaq BA
AD  - College of Medicine, University of Hail, Hail, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200831
PL  - Germany
TA  - Glob Med Genet
JT  - Global medical genetics
JID - 101769583
PMC - PMC7490123
OTO - NOTNLM
OT  - KRAS
OT  - colon cancer
OT  - gene expression
OT  - immunohistochemistry
OT  - type 2 diabetes
COIS- Conflict of Interest None declared.
EDAT- 2020/09/18 06:00
MHDA- 2020/09/18 06:01
PMCR- 2020/08/31
CRDT- 2020/09/17 05:45
PHST- 2020/09/17 05:45 [entrez]
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2020/09/18 06:01 [medline]
PHST- 2020/08/31 00:00 [pmc-release]
AID - 2000003 [pii]
AID - 10.1055/s-0040-1714415 [doi]
PST - ppublish
SO  - Glob Med Genet. 2020 Aug;7(2):35-40. doi: 10.1055/s-0040-1714415. Epub 2020 Aug 
      31.