PMID- 32939568 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1434-9949 (Electronic) IS - 0770-3198 (Linking) VI - 40 IP - 4 DP - 2021 Apr TI - Variation of red blood cell parameters in Behcet's disease: association with disease severity and vascular involvement. PG - 1457-1464 LID - 10.1007/s10067-020-05397-6 [doi] AB - INTRODUCTION/OBJECTIVES: Behcet's disease (BD) is a systemic and chronic inflammatory vasculitis with unknown etiology. Diagnosis is determined by evaluating several clinical criteria, but the lack of specific laboratory diagnostic markers makes the diagnosis of BD more difficult. Therefore, the aim of this study was to determine the changes in hematological parameters in BD patients to investigate their relationship with BD clinical features. METHOD: A total of 48 BD patients and 96 healthy controls were included in this study. The severity of each BD patient was associated to a severity score according to the entire spectrum of disease manifestations. Several laboratory tests were assessed, and the difference in their results between BD patients and healthy controls was evaluated. Correlation analysis was performed to reveal the interaction of these parameters. RESULTS: C-reactive protein (CRP), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), neutrophil count, platelet count, and plateletcrit significantly increased in BD patients compared with healthy controls (P < 0.05). CRP was higher in patients with skin lesions, MCH and MCHC were lower in patients with vascular involvement, and the neutrophil count was higher in patients with skin lesions and genital ulcers. In addition, higher CRP and lower MCH and MCHC were associated with a severe condition. Besides, MCH and MCHC were negatively correlated with the platelet count, plateletcrit, and neutrophil count. CONCLUSIONS: This study revealed that MCH and MCHC are valuable parameters for BD. Their levels help assess the disease severity and indicate the vascular involvement in BD. Key Points * This is the first study reporting MCH and MCHC as important biomarkers in BD. * BD patients with vascular involvement and thrombosis potential have lower levels of MCH and MCHC. * MCH and MCHC are negatively correlated with platelet count, plateletcrit, and neutrophil count. * Lower MCH and MCHC are associated with a severe condition. FAU - Cheng, Linlin AU - Cheng L AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. FAU - Li, Liubing AU - Li L AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. FAU - Liu, Chenxi AU - Liu C AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. FAU - Yan, Songxin AU - Yan S AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. FAU - Chen, Haizhen AU - Chen H AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Jilin, China. FAU - Li, Haolong AU - Li H AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. FAU - Zhang, Fengchun AU - Zhang F AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Chen, Hua AU - Chen H AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Li, Yongzhe AU - Li Y AD - Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. yongzhelipumch@126.com. LA - eng GR - 81671618/the National Natural Science Foundation of China Grants/ GR - 81871302/the National Natural Science Foundation of China Grants/ GR - 2017-I2M-3-001/CAMS Innovation Fund for Medical Sciences (CIFMS)/ GR - 2017-I2M-B&R-01/CAMS Innovation Fund for Medical Sciences (CIFMS)/ PT - Journal Article DEP - 20200916 PL - Germany TA - Clin Rheumatol JT - Clinical rheumatology JID - 8211469 SB - IM MH - *Behcet Syndrome/complications/diagnosis MH - Case-Control Studies MH - Erythrocyte Indices MH - Erythrocytes MH - Humans MH - Severity of Illness Index OTO - NOTNLM OT - Behcet's disease OT - Disease severity OT - Mean corpuscular hemoglobin OT - Mean corpuscular hemoglobin concentration OT - Vascular involvement EDAT- 2020/09/18 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/09/17 05:46 PHST- 2020/06/03 00:00 [received] PHST- 2020/09/12 00:00 [accepted] PHST- 2020/08/18 00:00 [revised] PHST- 2020/09/18 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/09/17 05:46 [entrez] AID - 10.1007/s10067-020-05397-6 [pii] AID - 10.1007/s10067-020-05397-6 [doi] PST - ppublish SO - Clin Rheumatol. 2021 Apr;40(4):1457-1464. doi: 10.1007/s10067-020-05397-6. Epub 2020 Sep 16.