PMID- 32940210
OWN - NLM
STAT- MEDLINE
DCOM- 20201027
LR  - 20201027
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 38 Suppl 126
IP  - 4
DP  - 2020 Jul-Aug
TI  - Positive histopathologic assessment in salivary glands shows little impact on 
      clinical features of established primary Sjogren's syndrome in a Korean 
      population.
PG  - 158-165
AB  - OBJECTIVES: The presence and severity of focal lymphocytic sialadenitis in minor 
      salivary glands is a pathognomonic feature in primary Sjogren's syndrome (pSS). 
      However, it has not been determined whether performing minor salivary gland 
      biopsy (MSGB) in a setting of serologically and clinically established pSS 
      provides additional clinical value. Therefore, we aimed to investigate the 
      necessity of MSGB in established pSS patients with anti-Ro/SSA antibodies. 
      METHODS: We extracted 185 patients with anti-Ro/SSA antibody-positive pSS from 
      the Korean Initiative of pSS study, a prospective cohort study. We assigned them 
      into two groups, 161 patients with focus scores >/=1 and another 24 with focus 
      scores <1. The two groups were compared in various clinical aspects, including 
      the severity of glandular dysfunction, systemic disease activity, extra- 
      glandular manifestations, and other clinical indices and laboratory values. We 
      also evaluated the relationship between focus scores and clinically important 
      variables in pSS. RESULTS: Between the two groups, there were no significant 
      differences in the severity of secretory dysfunction, the frequency of 
      extra-glandular manifestations, systemic disease activity represented by various 
      clinical indices, and laboratory findings possibly predicting the risk for 
      lymphoma. Rather, theSjogren's syndrome disease damage index was higher in the 
      group with focusscores <1. Among all variables, only serum immunoglobulin G 
      levels were correlated with focus scores. CONCLUSIONS: Given the little influence 
      on clinical phenotypes, routine MSGB could be omitted for serologically and 
      clinically established pSS patients, especially in low-risk areas for 
      lymphoproliferative diseases.
FAU - Park, Youngjae
AU  - Park Y
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Lee, Jennifer
AU  - Lee J
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Koh, Jung Hee
AU  - Koh JH
AD  - Division of Rheumatology, Department of Internal Medicine, Bucheon St. Mary's 
      Hospital, College of Medicine, the Catholic University of Korea, Bucheon, 
      Republic of Korea.
FAU - Choe, Jung Yoon
AU  - Choe JY
AD  - Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, 
      Republic of Korea.
FAU - Sung, Yoon-Kyoung
AU  - Sung YK
AD  - Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 
      Seoul, Republic of Korea.
FAU - Lee, Shin-Seok
AU  - Lee SS
AD  - Department of Rheumatology, Chonnam National University Medical School and 
      Hospital, Gwangju, Republic of Korea.
FAU - Shim, Seung-Cheol
AU  - Shim SC
AD  - Division of Rheumatology, Department of Internal Medicine, School of Medicine, 
      Chungnam National University, Chungnam National University Hospital, Daejeon, 
      Republic of Korea.
FAU - Kim, Ji-Min
AU  - Kim JM
AD  - Division of Rheumatology, Department of Internal Medicine, Keimyung University 
      Dongsan Medical Centre, Daegu, Republic of Korea.
FAU - Kwon, Sung Ryul
AU  - Kwon SR
AD  - Division of Rheumatology, Department of Internal Medicine, Inha University School 
      of Medicine, Incheon, Republic of Korea.
FAU - Park, Sung-Hwan
AU  - Park SH
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Kwok, Seung-Ki
AU  - Kwok SK
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea. seungki73@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200908
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Salivary Glands
MH  - Salivary Glands, Minor
MH  - *Sjogren's Syndrome/diagnosis/epidemiology
EDAT- 2020/09/18 06:00
MHDA- 2020/10/28 06:00
CRDT- 2020/09/17 08:46
PHST- 2020/04/07 00:00 [received]
PHST- 2020/07/13 00:00 [accepted]
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2020/10/28 06:00 [medline]
PHST- 2020/09/17 08:46 [entrez]
AID - 15607 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2020 Jul-Aug;38 Suppl 126(4):158-165. Epub 2020 Sep 8.