PMID- 32940695
OWN - NLM
STAT- MEDLINE
DCOM- 20210512
LR  - 20220218
IS  - 1753-4887 (Electronic)
IS  - 0029-6643 (Print)
IS  - 0029-6643 (Linking)
VI  - 79
IP  - 1
DP  - 2021 Jan 1
TI  - Effects of caloric restriction on human physiological, psychological, and 
      behavioral outcomes: highlights from CALERIE phase 2.
PG  - 98-113
LID - 10.1093/nutrit/nuaa085 [doi]
AB  - Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman 
      species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of 
      Energy (CALERIE) trials are part of a research program aiming to test the effects 
      of CR on aging and longevity biomarkers in humans. Building on CALERIE phase 1, 
      CALERIE phase 2 (CALERIE 2) was the largest study to date to assess sustained CR 
      in healthy humans without obesity. In a 24-month randomized controlled trial 
      comprising 218 participants at baseline, CALERIE 2 showed that moderate CR, 11.9% 
      on average, induced improvements in aging-related biomarkers without adversely 
      affecting psychological or behavioral outcomes. The objectives of this report are 
      to summarize and review the highlights of CALERIE 2 and report previously 
      unpublished results on eating disorder symptoms and cognitive function. This 
      article specifically summarizes the physiological, psychological, aging, 
      behavioral, and safety results of the trial. Also provided are research 
      directions beyond CALERIE 2 that highlight important opportunities to investigate 
      the role of CR in aging, longevity, and health span in humans.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      International Life Sciences Institute. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Dorling, James L
AU  - Dorling JL
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
FAU - van Vliet, Stephan
AU  - van Vliet S
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
FAU - Huffman, Kim M
AU  - Huffman KM
AD  - Duke University School of Medicine, Durham, North Carolina, USA.
FAU - Kraus, William E
AU  - Kraus WE
AD  - Duke University School of Medicine, Durham, North Carolina, USA.
FAU - Bhapkar, Manjushri
AU  - Bhapkar M
AD  - Duke University School of Medicine, Durham, North Carolina, USA.
FAU - Pieper, Carl F
AU  - Pieper CF
AD  - Duke University School of Medicine, Durham, North Carolina, USA.
FAU - Stewart, Tiffany
AU  - Stewart T
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
FAU - Das, Sai Krupa
AU  - Das SK
AD  - US Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging 
      at Tufts University, Boston, Massachusetts, USA.
FAU - Racette, Susan B
AU  - Racette SB
AD  - Washington University School of Medicine, St. Louis, Missouri, USA.
FAU - Roberts, Susan B
AU  - Roberts SB
AD  - US Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging 
      at Tufts University, Boston, Massachusetts, USA.
FAU - Ravussin, Eric
AU  - Ravussin E
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
FAU - Redman, Leanne M
AU  - Redman LM
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
FAU - Martin, Corby K
AU  - Martin CK
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
CN  - CALERIE Study Group
LA  - eng
GR  - U01 AG020487/AG/NIA NIH HHS/United States
GR  - U01 AG020478/AG/NIA NIH HHS/United States
GR  - U01 AG020480/AG/NIA NIH HHS/United States
GR  - U01 AG022132/AG/NIA NIH HHS/United States
GR  - P30 DK072476/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - U54 GM104940/GM/NIGMS NIH HHS/United States
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nutr Rev
JT  - Nutrition reviews
JID - 0376405
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - *Aging
MH  - Biomarkers/*analysis
MH  - *Caloric Restriction
MH  - *Energy Intake
MH  - Energy Metabolism
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Longevity
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - Obesity
MH  - Oxidative Stress
MH  - Young Adult
PMC - PMC7727025
OTO - NOTNLM
OT  - aging
OT  - longevity
OT  - metabolism
OT  - quality of life
OT  - randomized controlled trial
EDAT- 2020/09/18 06:00
MHDA- 2021/05/13 06:00
PMCR- 2021/09/17
CRDT- 2020/09/17 12:16
PHST- 2020/04/16 00:00 [received]
PHST- 2020/06/01 00:00 [revised]
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2021/05/13 06:00 [medline]
PHST- 2020/09/17 12:16 [entrez]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 5907056 [pii]
AID - nuaa085 [pii]
AID - 10.1093/nutrit/nuaa085 [doi]
PST - ppublish
SO  - Nutr Rev. 2021 Jan 1;79(1):98-113. doi: 10.1093/nutrit/nuaa085.