PMID- 32941737
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20211020
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 46
IP  - 4
DP  - 2021 Apr
TI  - Prior ingestion of a ketone monoester supplement reduces postprandial glycemic 
      responses in young healthy-weight individuals.
PG  - 309-317
LID - 10.1139/apnm-2020-0644 [doi]
AB  - The main objective of this study was to determine whether acute ingestion of a 
      ketone monoester (KME) supplement impacted mixed-meal tolerance test (MMTT) 
      glucose area under the curve (AUC). Nineteen healthy young volunteers (10 males/9 
      females; age, 24.7 +/- 4.9 years; body mass index, 22.7 +/- 2.4 kg/m(2)) participated 
      in a double-blind, placebo-controlled crossover study. Following overnight 
      fasting (>/=10 h), participants consumed 0.45 mL/kg of a KME supplement or 
      taste-matched placebo followed by an MMTT 15 min later. Blood samples were 
      collected every 15-30 min over 2.5 h. KME supplementation acutely raised 
      beta-hydroxybutyrate AUC (590%, P < 0.0001, d = 2.4) and resulted in decreases in 
      blood glucose AUC (-9.4%, P = 0.03, d = 0.56) and nonesterified fatty acid (NEFA) 
      AUC (-27.3%, P = 0.023, d = 0.68) compared with placebo. No differences were 
      found for plasma insulin AUC (P = 0.70) or gastric emptying estimated by 
      co-ingested acetaminophen AUC (P = 0.96) between ketone and placebo. Overall, 
      results indicate that KME supplementation attenuates postprandial glycemic and 
      NEFA responses when taken 15 min prior to a mixed meal in young healthy 
      individuals. Future studies are warranted to investigate whether KME 
      supplementation may benefit individuals with impaired glycemic control. Novelty: 
      Acute ketone monoester supplementation 15 min prior to a mixed meal decreased 
      postprandial glucose and NEFA levels without significantly impacting postprandial 
      insulin or estimates of gastric emptying. Glucose- and NEFA-lowering effects of 
      ketone monoester supplementation are apparently not mediated by changes in 
      insulin release or gastric emptying.
FAU - Greaves, Grant
AU  - Greaves G
AD  - Faculty of Medicine, The University of British Columbia, Okanagan Campus, 
      Kelowna, BC V1V 1V7, Canada.
FAU - Xiang, Richard
AU  - Xiang R
AD  - Faculty of Medicine, The University of British Columbia, Okanagan Campus, 
      Kelowna, BC V1V 1V7, Canada.
FAU - Rafiei, Hossein
AU  - Rafiei H
AD  - School of Health and Exercise Sciences, The University of British Columbia, 
      Okanagan Campus, Kelowna, BC V1V 1V7, Canada.
FAU - Malas, Adeeb
AU  - Malas A
AD  - Faculty of Medicine, The University of British Columbia, Okanagan Campus, 
      Kelowna, BC V1V 1V7, Canada.
FAU - Little, Jonathan P
AU  - Little JP
AD  - School of Health and Exercise Sciences, The University of British Columbia, 
      Okanagan Campus, Kelowna, BC V1V 1V7, Canada.
LA  - eng
PT  - Journal Article
DEP - 20200917
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Ketones)
SB  - IM
MH  - Adult
MH  - *Blood Glucose
MH  - Cross-Over Studies
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Eating
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Gastric Emptying
MH  - Humans
MH  - Insulin/blood
MH  - Ketones/*administration & dosage
MH  - Male
MH  - Meals
MH  - Postprandial Period
MH  - Young Adult
OTO - NOTNLM
OT  - carbohydrate metabolism
OT  - controle glycemique
OT  - cetones exogenes
OT  - exogenous ketones
OT  - glycemic control
OT  - glycemie postprandiale
OT  - insulin resistance
OT  - insulinoresistance
OT  - ketone supplement
OT  - metabolisme des glucides
OT  - postprandial glycemia
OT  - supplement de cetone
OT  - beta-hydroxybutyrate
EDAT- 2020/09/18 06:00
MHDA- 2021/10/21 06:00
CRDT- 2020/09/17 20:11
PHST- 2020/09/18 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2020/09/17 20:11 [entrez]
AID - 10.1139/apnm-2020-0644 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2021 Apr;46(4):309-317. doi: 10.1139/apnm-2020-0644. 
      Epub 2020 Sep 17.