PMID- 32943313
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 227
DP  - 2021 Jan
TI  - Concordance and factor structure of subthreshold positive symptoms in youth at 
      clinical high risk for psychosis.
PG  - 72-77
LID - S0920-9964(20)30442-4 [pii]
LID - 10.1016/j.schres.2020.08.014 [doi]
AB  - Prevailing models of psychosis risk incorporate positive subthreshold symptoms as 
      defining features of risk or transition to psychotic disorders. Despite this, 
      relatively few studies have focused on characterizing longitudinal symptom 
      features, such as prevalence, concordance and structure, which may aid in 
      refining methods and enhancing classification and prediction efforts. The present 
      study aimed to fill these gaps using longitudinal 24-month follow-up data from 
      the well-characterized NAPLS-2 multi-site investigation of youth at clinical high 
      risk (CHR) who had (n = 86) and had not (n = 268) transitioned to a threshold 
      psychotic disorder since baseline. At baseline, among sub-delusional ideas, 
      unusual thought content and suspicious/persecutory thinking were very common in 
      CHR youth, and were highly concordant. Perceptual abnormalities (P4) were also 
      common across youth regardless of symptom course and eventual transition to 
      psychosis. Grandiose ideas were rare. Exploratory factor analysis extracted two 
      constituent factors at multiple follow-up intervals, but there was marked 
      instability in the structure over 24 months, and clear indicators for a single 
      positive symptom factor. Together these findings support suggestions to combine 
      sub-delusional symptoms into a single symptom category for classification 
      purposes, in efforts to reduce clinical heterogeneity and ease measurement 
      burden.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Calkins, Monica E
AU  - Calkins ME
AD  - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United 
      States of America. Electronic address: mcalkins@pennmedicine.upenn.edu.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, United States of 
      America.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Departments of Psychology and Psychiatry and Biobehavioral Sciences, UCLA, Los 
      Angeles, CA, United States of America.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
FAU - Moore, Tyler M
AU  - Moore TM
AD  - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United 
      States of America.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry, UCSD, La Jolla, CA, United States of America.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, United States of 
      America.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United 
      States of America.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, New Haven, CT, United States of 
      America.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United 
      States of America.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, United States of 
      America.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, UCSD, La Jolla, CA, United States of America.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, United 
      States of America.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      CA, United States of America.
FAU - Keshavan, Matcheri
AU  - Keshavan M
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, United States of 
      America.
FAU - Stone, William S
AU  - Stone WS
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, United States of 
      America.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
LA  - eng
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200915
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Delusions
MH  - Humans
MH  - *Prodromal Symptoms
MH  - *Psychotic Disorders/diagnosis/epidemiology
OTO - NOTNLM
OT  - Attenuated psychosis symptoms
OT  - Clinically high-risk
OT  - Psychosis
COIS- Declaration of competing interest The authors have declared that there are no 
      conflicts of interest with respect to this paper.
EDAT- 2020/09/19 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/18 05:37
PHST- 2020/04/02 00:00 [received]
PHST- 2020/08/13 00:00 [revised]
PHST- 2020/08/16 00:00 [accepted]
PHST- 2020/09/19 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/18 05:37 [entrez]
AID - S0920-9964(20)30442-4 [pii]
AID - 10.1016/j.schres.2020.08.014 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 Jan;227:72-77. doi: 10.1016/j.schres.2020.08.014. Epub 2020 
      Sep 15.