PMID- 32944598
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 32
DP  - 2020 Oct
TI  - Dataset on amelogenesis-related genes variants (ENAM and ENAM interacting genes) 
      and on human leukocyte antigen alleles (DQ2 and DQ8) distribution in children 
      with and without molar-incisor hypomineralisation (MIH).
PG  - 106224
LID - 10.1016/j.dib.2020.106224 [doi]
LID - 106224
AB  - All children, who were born in 2004 and had undergone surgical treatment for 
      recurrent acute tonsillitis and/or acute otitis media at the ear, nose and throat 
      clinic (ENT) between 2004 and 2010, were called on dental examination and blood 
      sampling. Out of 441 invitees, 113 children and their parents/legal guardians 
      agreed to participate. The following data from this group of subjects are 
      presented: the presence of clinical signs of molar-incisor hypomineralisation 
      (MIH), the distribution of human leukocyte antigen (HLA) alleles DQ2 and DQ8 and 
      eight single nucleotide polymorphisms (SNPs) located in amelogenesis-related 
      genes (rs3796704 in the ENAM gene, rs546778141 in the AMBN gene, rs2106416 in the 
      AMELX gene, rs7660807 and rs35286445 in the AMTN gene, rs4870723 in the COL14A1 
      gene, rs2245803 in the MMP20 gene, and rs3828054 in the TUFT1 gene). Data on 
      clinical signs of MIH were collected in accordance with the recommendation and on 
      the proposed MIH clinical data recording sheet [1], and with appropriate 
      preliminary training and calibration. Data on HLA DQ2 and DQ8 haplotypes and on 
      SNPs of amelogenesis-related genes were obtained using DNA isolated from blood 
      samples taken from subjects. The HLA DQ2 and DQ8 alleles were determined using 
      the EliGene(R) Coeliac RT Kits (90,048-RT; Elisabeth Pharmacon spol. s.r.o., 
      Brno-Zidenice, Czech Republic) on a 7500 Fast RT-PCR System (Applied Biosystems, 
      Waltham, MA, USA). The distributions of SNPs in the amelogenesis-related genes 
      were determined using high resolution melting (HRM) using the Type-IT HRM Master 
      Mix (Qiagen), TaqMan genotyping assays (ID: C__25766207_10; Thermo Fisher 
      Scientific, Waltham, MA, USA) with the TaqMan Universal Master Mix II, or Sanger 
      sequencing using sequencing master mix BigDye(R) Terminator v3.1 (Applied 
      Biosystems) and ABI 3500 Genetic Analyser (Applied Biosystems). L. Hocevar, J. 
      Kovac, K. Trebusak Podkrajsek, S. Battelino, A. Pavlic, 2020. The possible 
      influence of genetic aetiological 
      factors on molar-incisor hypomineralisation, Arch. Oral. Biol. 118, 104848. 
      https://doi.org/10.1016/j.archoralbio.2020.104848.
CI  - (c) 2020 The Author(s). Published by Elsevier Inc.
FAU - Hocevar, Luka
AU  - Hocevar L
AD  - Department of Paediatric and Preventive Dentistry, Faculty of Medicine, 
      University of Ljubljana, Hrvatski trg 6, Ljubljana 1000, Slovenia.
FAU - Kovac, Jernej
AU  - Kovac J
AD  - University Children's Hospital, University Medical Centre Ljubljana, Bohoriceva 
      20, Ljubljana, Slovenia.
FAU - Podkrajsek, Katarina Trebusak
AU  - Podkrajsek KT
AD  - University Children's Hospital, University Medical Centre Ljubljana, Bohoriceva 
      20, Ljubljana, Slovenia.
AD  - Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov 
      trg 2, Ljubljana, Slovenia.
FAU - Battelino, Saba
AU  - Battelino S
AD  - Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical 
      Centre Ljubljana, Zaloska 2, Ljubljana, Slovenia.
AD  - Department of Otorhinolaryngology, Faculty of Medicine, University of Ljubljana, 
      Vrazov trg 2, Ljubljana, Slovenia.
FAU - Pavlic, Alenka
AU  - Pavlic A
AD  - Department of Paediatric and Preventive Dentistry, Faculty of Medicine, 
      University of Ljubljana, Hrvatski trg 6, Ljubljana 1000, Slovenia.
AD  - Department of Paediatric and Preventive Dentistry, University Medical Centre 
      Ljubljana, Hrvatski trg 6, Ljubljana, Slovenia.
LA  - eng
PT  - Journal Article
DEP - 20200825
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC7481823
OTO - NOTNLM
OT  - Aetiology
OT  - CADD, Combined annotation dependent depletion
OT  - ENT, ear, nose and throat clinic
OT  - FPM, First permanent molar
OT  - HLA, human leukocyte antigen
OT  - HRM, high resolution melting
OT  - Human leukocyte antigen
OT  - MIH, molar-incisor hypomineralisation
OT  - Molar-incisor hypomineralisation
OT  - PEB, Post-eruptive enamel breakdown
OT  - SNP, single nucleotide polymorphism
OT  - Single nucleotide polymorphism
OT  - The amelogenesis-related genes
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships which have, or could be perceived to have, influenced the 
      work reported in this article.
EDAT- 2020/09/19 06:00
MHDA- 2020/09/19 06:01
PMCR- 2020/08/25
CRDT- 2020/09/18 05:51
PHST- 2020/07/30 00:00 [received]
PHST- 2020/08/20 00:00 [revised]
PHST- 2020/08/21 00:00 [accepted]
PHST- 2020/09/18 05:51 [entrez]
PHST- 2020/09/19 06:00 [pubmed]
PHST- 2020/09/19 06:01 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - S2352-3409(20)31118-5 [pii]
AID - 106224 [pii]
AID - 10.1016/j.dib.2020.106224 [doi]
PST - epublish
SO  - Data Brief. 2020 Aug 25;32:106224. doi: 10.1016/j.dib.2020.106224. eCollection 
      2020 Oct.