PMID- 32946469
OWN - NLM
STAT- MEDLINE
DCOM- 20201103
LR  - 20201103
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 9
DP  - 2020
TI  - Preoperative diagnoses and identification rates of unexpected gallbladder cancer.
PG  - e0239178
LID - 10.1371/journal.pone.0239178 [doi]
LID - e0239178
AB  - BACKGROUND: Unexpected gallbladder cancer (UGBC) is sometimes found in the 
      resected gallbladder of patients during or after surgery. Some reports have 
      indicated UGBC identification rates for all gallbladder surgeries, but scarce 
      data are available for the UGBC identification rates for specific gallbladder 
      diseases. The present study was performed to clarify UGBC rates and the factors 
      suspicious for UGBC categorized according to preoperative diagnoses, in patients 
      undergoing laparoscopic cholecystectomy (LSC). METHODS: We recorded data for all 
      LSC surgeries performed in the Department of Surgery, Sada Hospital, Japan since 
      1991, and analyzed the 28-year data. We used the chi-square test and Kaplan-Meier 
      analysis for this retrospective case-control study. RESULTS: The UGBC 
      identification rate was 0.69% (63/9186 patients). The UGBC identification rates 
      categorized according to the preoperative diagnoses were 1.3% (13/969) for acute 
      cholecystitis, 2.4% (16/655) for benign tumor, 2.0% (28/1383) for chronic 
      cholecystitis or cholecystitis, and 0.054% (3/5585) for cholecystolithiasis. The 
      percentage of older patients (>/= 60 years) was significantly higher in UGBCs 
      compared with cases finally diagnosed as benign in each group categorized 
      according to the preoperative diagnoses (p</=0.0014), except for 
      cholecystolithiasis. In cases pre-diagnosed as benign tumor, UGBCs were 
      associated with higher rates of thickened gallbladder wall compared with benign 
      tumor (69.2% vs. 27.9%, respectively; p = 0.0011). UGBCs pre-diagnosed as acute 
      cholecystitis had higher T2-T4 rates (100% vs. 64.3%, respectively; p<0.05) and 
      lower survival rates (p = 0.0149) than UGBCs pre-diagnosed with chronic 
      cholecystitis. CONCLUSIONS: UGBC identification rates depend on the preoperative 
      diagnosis and range from 0.054% to 2.4%. Older age (>/= 60 years) could be related 
      to UGBC, and a pre-diagnosis of acute cholecystitis might indicate more advanced 
      cancer compared with a pre-diagnosis of chronic cholecystitis.
FAU - Fujiwara, Kenji
AU  - Fujiwara K
AUID- ORCID: 0000-0001-5900-9382
AD  - Department of Surgery, Sada Hospital, Fukuoka, Japan.
FAU - Masatsugu, Toshihiro
AU  - Masatsugu T
AD  - Department of Surgery, Sada Hospital, Fukuoka, Japan.
FAU - Abe, Atsushi
AU  - Abe A
AD  - Department of Surgery, Sada Hospital, Fukuoka, Japan.
FAU - Hirano, Tatsuya
AU  - Hirano T
AD  - Department of Surgery, Sada Hospital, Fukuoka, Japan.
FAU - Sada, Masayuki
AU  - Sada M
AD  - Department of Surgery, Sada Hospital, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200918
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - *Cholecystectomy
MH  - Cholecystitis, Acute/*diagnosis/pathology/surgery
MH  - Cholecystolithiasis/*diagnosis/pathology/surgery
MH  - Chronic Disease
MH  - Female
MH  - Gallbladder Neoplasms/diagnosis/*epidemiology/pathology
MH  - Humans
MH  - *Incidental Findings
MH  - Japan/epidemiology
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Preoperative Period
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Young Adult
PMC - PMC7500683
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/09/19 06:00
MHDA- 2020/11/04 06:00
PMCR- 2020/09/18
CRDT- 2020/09/18 17:12
PHST- 2020/05/22 00:00 [received]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/09/18 17:12 [entrez]
PHST- 2020/09/19 06:00 [pubmed]
PHST- 2020/11/04 06:00 [medline]
PHST- 2020/09/18 00:00 [pmc-release]
AID - PONE-D-20-15344 [pii]
AID - 10.1371/journal.pone.0239178 [doi]
PST - epublish
SO  - PLoS One. 2020 Sep 18;15(9):e0239178. doi: 10.1371/journal.pone.0239178. 
      eCollection 2020.