PMID- 32946948 OWN - NLM STAT- MEDLINE DCOM- 20220215 LR - 20220215 IS - 1878-4216 (Electronic) IS - 0278-5846 (Linking) VI - 111 DP - 2021 Dec 20 TI - Heart rate variability is associated with disease severity in psychosis spectrum disorders. PG - 110108 LID - S0278-5846(20)30424-3 [pii] LID - 10.1016/j.pnpbp.2020.110108 [doi] AB - While a growing literature links cardiac autonomic dysregulation to a variety of psychiatric disorders, the relationship between cardiac autonomic functioning and specific symptoms in schizophrenia (SZ) and bipolar disorder (BD) remains elusive. Thus, we investigated heart rate variability (HRV), a proxy for vagal activity, as a biological marker for symptom severity in patients with SZ and BD. HRV was calculated in 35 patients with SZ and 52 patients with BD, as well as in 149 healthy controls. In the patient groups, symptom severity and function were measured by the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF) scale. Results showed that HRV was significantly lower in both clinical groups compared to the healthy controls, with no significant HRV differences between patient groups. PANSS general psychopathology scores, GAF symptom scores, and GAF function scores showed statistically significant associations with HRV across groups. These results suggest that disease severity is associated with autonomic dysfunction and that HRV may provide a potential biomarker of disease severity in SZ and BD. CI - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Benjamin, Beatrice R AU - Benjamin BR AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark. FAU - Valstad, Mathias AU - Valstad M AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Elvsashagen, Torbjorn AU - Elvsashagen T AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. FAU - Jonsson, Erik G AU - Jonsson EG AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden. FAU - Moberget, Torgeir AU - Moberget T AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway. FAU - Winterton, Adriano AU - Winterton A AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Haram, Marit AU - Haram M AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Hoegh, Margrethe C AU - Hoegh MC AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Lagerberg, Trine V AU - Lagerberg TV AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Steen, Nils Eiel AU - Steen NE AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway. FAU - Larsen, Lars AU - Larsen L AD - Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark. FAU - Andreassen, Ole A AU - Andreassen OA AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. FAU - Westlye, Lars T AU - Westlye LT AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. FAU - Quintana, Daniel S AU - Quintana DS AD - NORMENT, Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. Electronic address: daniel.quintana@medisin.uio.no. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200915 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Biomarkers) SB - IM MH - Adult MH - Autonomic Nervous System/physiopathology MH - Biomarkers MH - Bipolar Disorder/*physiopathology MH - Brief Psychiatric Rating Scale/statistics & numerical data MH - Female MH - Heart Rate/*physiology MH - Humans MH - Male MH - Psychotic Disorders/*physiopathology MH - *Severity of Illness Index OTO - NOTNLM OT - Bipolar disorder OT - Heart rate variability OT - Psychosis OT - Schizophrenia EDAT- 2020/09/19 06:00 MHDA- 2022/02/16 06:00 CRDT- 2020/09/18 20:13 PHST- 2020/05/19 00:00 [received] PHST- 2020/09/09 00:00 [revised] PHST- 2020/09/11 00:00 [accepted] PHST- 2020/09/19 06:00 [pubmed] PHST- 2022/02/16 06:00 [medline] PHST- 2020/09/18 20:13 [entrez] AID - S0278-5846(20)30424-3 [pii] AID - 10.1016/j.pnpbp.2020.110108 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110108. doi: 10.1016/j.pnpbp.2020.110108. Epub 2020 Sep 15.