PMID- 32948139 OWN - NLM STAT- MEDLINE DCOM- 20210902 LR - 20210902 IS - 1471-2202 (Electronic) IS - 1471-2202 (Linking) VI - 21 IP - 1 DP - 2020 Sep 18 TI - Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis. PG - 39 LID - 10.1186/s12868-020-00589-x [doi] LID - 39 AB - BACKGROUND: ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. METHODS: The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. RESULTS: In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p < 0.05 (AlphaSim correction). CONCLUSION: The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements. FAU - Zhang, Huayu AU - Zhang H AD - Shandong University of Science and Technology, No. 579, Qianwan' gang Road, Qingdao, 266590, Shandong, China. FAU - Zhao, Yue AU - Zhao Y AD - Shandong University of Science and Technology, No. 579, Qianwan' gang Road, Qingdao, 266590, Shandong, China. AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. FAU - Cao, Weifang AU - Cao W AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. AD - Radiology Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China. FAU - Cui, Dong AU - Cui D AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. AD - Radiology Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China. FAU - Jiao, Qing AU - Jiao Q AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. AD - Radiology Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China. FAU - Lu, Weizhao AU - Lu W AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. AD - Radiology Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China. FAU - Li, Hongyu AU - Li H AD - Shandong University of Science and Technology, No. 579, Qianwan' gang Road, Qingdao, 266590, Shandong, China. skdlhy@163.com. FAU - Qiu, Jianfeng AU - Qiu J AUID- ORCID: 0000-0002-8049-3743 AD - Medical Engineering and Technology Research Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China. jfqiu100@gmail.com. AD - Radiology Department, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China. jfqiu100@gmail.com. LA - eng GR - 2016YFC0103400/National Key Research and Development Program/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200918 PL - England TA - BMC Neurosci JT - BMC neuroscience JID - 100966986 SB - IM MH - Adolescent MH - Attention MH - Attention Deficit Disorder with Hyperactivity/diagnostic imaging/*physiopathology MH - Cerebral Cortex/diagnostic imaging/physiopathology MH - Child MH - Default Mode Network MH - Executive Function MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Nerve Net/physiopathology MH - Neural Pathways/diagnostic imaging/*physiopathology MH - Parietal Lobe/physiopathology MH - Principal Component Analysis MH - Rest MH - Temporal Lobe/physiopathology PMC - PMC7501693 OTO - NOTNLM OT - ADHD OT - Functional connectivity OT - ICA OT - RSNs OT - fMRI COIS- The authors declare that they have no competing interests. EDAT- 2020/09/20 06:00 MHDA- 2021/09/03 06:00 PMCR- 2020/09/18 CRDT- 2020/09/19 05:23 PHST- 2019/10/17 00:00 [received] PHST- 2020/09/09 00:00 [accepted] PHST- 2020/09/19 05:23 [entrez] PHST- 2020/09/20 06:00 [pubmed] PHST- 2021/09/03 06:00 [medline] PHST- 2020/09/18 00:00 [pmc-release] AID - 10.1186/s12868-020-00589-x [pii] AID - 589 [pii] AID - 10.1186/s12868-020-00589-x [doi] PST - epublish SO - BMC Neurosci. 2020 Sep 18;21(1):39. doi: 10.1186/s12868-020-00589-x.