PMID- 32948895
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 278
IP  - 2
DP  - 2021 Feb
TI  - Assessment of side effects after serial intralesional steroid injections for 
      idiopathic subglottic stenosis.
PG  - 445-450
LID - 10.1007/s00405-020-06371-3 [doi]
AB  - PURPOSE: To assess the incidence and severity of 12 systemic side effects of 
      serial intralesional steroid injections (SILSI) in patients with idiopathic 
      subglottic stenosis (iSGS). METHODS: This retrospective study included patients 
      with iSGS who underwent SILSI with Triamcinolone 40 mg/dL. After SILSI, the 
      patients were asked to answer 12 questions regarding frequently encountered 
      systemic side effects of steroids. Each answer was rated as mild, moderate, or 
      severe. Descriptive statistics were used to analyze and present the findings. 
      RESULTS: The study included 49 patients (42 female and 7 male) with a mean age of 
      59.1 years (range 21-83 years). Post-SILSI treatment, 27 (55%) reported 
      experiencing side effects while 22 (45%) patients reported no side effects. The 
      most frequent side effect reported in women of reproductive age (n: 8) was 
      menstrual irregularities (3/8, 37%). Other frequently reported side effects were 
      feeling joyful and sleeping difficulties, each reported by 30% of the patients. 
      All side effects resolved after the completion of SILSI. CONCLUSIONS: SILSI can 
      be administered with minimal tolerable side effects. Clinicians should make their 
      patients aware of the most frequent side effects. Special attention should be 
      given to women of reproductive age to inform them of the possibility of menstrual 
      irregularities during SILSI.
FAU - Celebi, Ozlem Onerci
AU  - Celebi OO
AD  - Istanbul Training and Research Hospital, Otolaryngology Head and Neck Surgery 
      Clinic, Istanbul, Turkey.
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
FAU - Song, Sungjin A
AU  - Song SA
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medica School, Boston, MA, USA.
FAU - Santeerapharp, Alena
AU  - Santeerapharp A
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Srinakharinwirot 
      University, Bangkok, Thailand.
FAU - Choksawad, Kanittha
AU  - Choksawad K
AD  - Department of Otolaryngology, Panyananthapikkhu Chonprathan Medical Center 
      Srinakharinwirot University, Bangkok, Thailand.
FAU - Franco, Ramon A Jr
AU  - Franco RA Jr
AUID- ORCID: 0000-0002-4549-6017
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA. 
      Ramon_Franco@meei.harvard.edu.
AD  - Department of Otolaryngology, Harvard Medica School, Boston, MA, USA. 
      Ramon_Franco@meei.harvard.edu.
AD  - Division of Laryngology, Department of Otolaryngology, Voice and Speech 
      Laboratory, Mass Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, 
      MA, 02114, USA. Ramon_Franco@meei.harvard.edu.
LA  - eng
PT  - Journal Article
DEP - 20200918
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Glucocorticoids)
RN  - 0 (Steroids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Constriction, Pathologic
MH  - Female
MH  - Glucocorticoids/adverse effects
MH  - Humans
MH  - Injections, Intralesional
MH  - *Laryngostenosis/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Steroids/therapeutic use
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Intralesional steroid injection
OT  - Local steroid treatment
OT  - Steroid side effects
OT  - Subglottic stenosis
EDAT- 2020/09/20 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/09/19 05:33
PHST- 2020/08/24 00:00 [received]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/09/20 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/09/19 05:33 [entrez]
AID - 10.1007/s00405-020-06371-3 [pii]
AID - 10.1007/s00405-020-06371-3 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2021 Feb;278(2):445-450. doi: 
      10.1007/s00405-020-06371-3. Epub 2020 Sep 18.