PMID- 32949652
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 169
DP  - 2020 Nov
TI  - Circulating levels of CTRP3 in patients with type 2 diabetes mellitus compared to 
      controls: A systematic review and meta-analysis.
PG  - 108453
LID - S0168-8227(20)30706-3 [pii]
LID - 10.1016/j.diabres.2020.108453 [doi]
AB  - Growing evidence suggests that adipokines may be therapeutic targets for 
      cardiometabolic diseases such as type 2 diabetes mellitus (T2DM). C1q TNF Related 
      Protein 3 (CTRP3) is a newly discovered adipokine which shares properties with 
      adiponectin. The literature about the association between circulating levels of 
      CTRP3 and T2DM has been conflicting. The present study reassessed the data on 
      circulating CTRP3 levels in T2DM patients compared to controls through a 
      systematic review and meta-analysis. A literature search was performed in 
      Medline, Embase, Scopus, and Web of science to identify studies that measured 
      circulating CTRP3 levels in T2DM patients and controls. The search identified 124 
      studies of which 59 were screened for title and abstract and 13 were subsequently 
      screened at the full text stage and 12 studies included into the meta-analysis. 
      Subgroup analyses, depending on the presence of T2DM complications, matching for 
      BMI, age, and cut off value of fasting blood sugar and HOMA-IR, were performed. 
      The results show that circulating CTRP3 levels are negatively associated with 
      T2DM status (SMD: -0.837; 95% CI: (-1.656 to -0.017); p = 0.045). No publication 
      bias was identified using the Begg's rank correlation and Egger's linear 
      regression tests (P = 1 and P = 0.44, respectively). Meta-regression demonstrated 
      significant association between CRTP3 levels with BMI (slope: 0.11; 95% CI: 
      0.04-0.19; p = 0.001) and sex (slope: -0.07; 95% CI: -0.12 to -0.01; p = 0.008). 
      The present systematic review and meta-analysis evidences a negative association 
      between circulating level of CTRP3 and T2DM status. BMI and sex may modify this 
      association.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Moradi, Nariman
AU  - Moradi N
AD  - Cellular and Molecular Research Center, Research Institute for Health 
      Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
FAU - Najafi, Mohammad
AU  - Najafi M
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran.
FAU - Sharma, Tanmay
AU  - Sharma T
AD  - Department of Health Research Methods, Evidence, and Impact, McMaster University, 
      Hamilton, Canada.
FAU - Fallah, Soudabeh
AU  - Fallah S
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran.
FAU - Koushki, Mehdi
AU  - Koushki M
AD  - Proteomics Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran; Department of Biochemistry, School of Medicine, Zanjan University 
      of Medical Sciences, Zanjan, Iran.
FAU - Peterson, Jonathan M
AU  - Peterson JM
AD  - Department of Health Sciences, College of Public Health, East Tennessee State 
      University, Johnson City, TN, United States; Quillen College of Medicine, 
      Department of Biomedical Sciences, East Tennessee State University, Johnson City, 
      TN, United States.
FAU - Meyre, David
AU  - Meyre D
AD  - Department of Health Research Methods, Evidence, and Impact, McMaster University, 
      Hamilton, Canada; Department of Pathology and Molecular Medicine, McMaster 
      University, Hamilton, Canada. Electronic address: meyred@mcmaster.ca.
FAU - Fadaei, Reza
AU  - Fadaei R
AD  - Sleep Disorders Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran. Electronic address: Fadaeirf@gmail.com.
LA  - eng
GR  - R15 DK114740/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200917
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (C1QTNF3 protein, human)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Tumor Necrosis Factors/*metabolism
OTO - NOTNLM
OT  - Adipokine
OT  - CTRP
OT  - Diabetes
OT  - Insulin resistance
OT  - Meta-analysis
OT  - Review
EDAT- 2020/09/20 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/09/19 20:09
PHST- 2020/08/06 00:00 [received]
PHST- 2020/08/28 00:00 [revised]
PHST- 2020/09/13 00:00 [accepted]
PHST- 2020/09/20 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/09/19 20:09 [entrez]
AID - S0168-8227(20)30706-3 [pii]
AID - 10.1016/j.diabres.2020.108453 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 Nov;169:108453. doi: 10.1016/j.diabres.2020.108453. 
      Epub 2020 Sep 17.