PMID- 32950433
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 2213-2945 (Print)
IS  - 2213-2953 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Mar-Apr
TI  - Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis 
      on fine-needle aspiration biopsy.
PG  - 231-238
LID - S2213-2945(20)30280-5 [pii]
LID - 10.1016/j.jasc.2020.08.009 [doi]
AB  - INTRODUCTION: Metastatic prostatic adenocarcinoma (PAC) has mostly involved the 
      pelvic lymph nodes; metastases to the cervical lymph nodes are exceedingly rare. 
      MATERIALS AND METHODS: A retrospective review of cytopathology files (January 
      1990 to March 2019) identified 13 cases of metastatic PAC to cervical lymph nodes 
      diagnosed using fine-needle aspiration biopsy (FNAB). The clinical and 
      demographic information were collected from the electronic medical records, and 
      the slides were reviewed. RESULTS: A total of 13 male patients with a mean age at 
      FNAB 69 years (range, 61-86 years); 12 patients had a known history of PAC. In 
      the patient without a history of PAC, the FNAB finding had been misinterpreted as 
      papillary thyroid carcinoma. The interval between the original diagnosis and 
      cervical lymph node metastasis was 98.5 months (range, 1-288 months). Most 
      involved the left side (85%). Most smears had a clean background with few 
      lymphocytes (46%) and numerous cellular clusters in flat sheets and acini (62%) 
      and were composed of polygonal cells (46%) with round-oval shaped nuclei and 
      indistinct cell borders (92%). The cytoplasm was granular (61%) or scanty (46%). 
      The nuclei were uniform, size >/=2 times that of a neutrophil (69%). Prominent 
      nucleoli and anisonucleosis were seen in 54% of cases; cellular pleomorphism was 
      infrequent (30%). Immunostains confirmed the prostate origin in 7 tissue cores. 
      CONCLUSIONS: Metastatic PAC to the cervical lymph nodes occurs infrequently. If 
      the history is unknown, cases can be misdiagnosed as metastases from cervical 
      neoplasms. The findings indicating metastatic PAC to the cervical lymph nodes on 
      FNAB include involvement of left-sided cervical lymph nodes in elderly male 
      patients and cellular smears composed of uniform polygonal cells, arranged in 
      flat sheets and acini, with granular cytoplasm, indistinct cell borders, and 
      round-oval nuclei with prominent nucleoli.
CI  - Copyright (c) 2021 American Society of Cytopathology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Albadri, Sam T
AU  - Albadri ST
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
FAU - Salomao, Diva
AU  - Salomao D
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota. Electronic 
      address: Salomao.Diva@mayo.edu.
LA  - eng
PT  - Journal Article
DEP - 20200825
PL  - United States
TA  - J Am Soc Cytopathol
JT  - Journal of the American Society of Cytopathology
JID - 101613234
SB  - IM
MH  - Adenocarcinoma/diagnosis/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Fine-Needle
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Neck
MH  - Prostatic Neoplasms/diagnosis/*pathology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - FNAB
OT  - Lymph node
OT  - Metastatic adenocarcinoma
OT  - Neck
OT  - Prostate adenocarcinoma
EDAT- 2020/09/21 06:00
MHDA- 2022/01/07 06:00
CRDT- 2020/09/20 20:26
PHST- 2020/05/14 00:00 [received]
PHST- 2020/07/10 00:00 [revised]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/09/21 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2020/09/20 20:26 [entrez]
AID - S2213-2945(20)30280-5 [pii]
AID - 10.1016/j.jasc.2020.08.009 [doi]
PST - ppublish
SO  - J Am Soc Cytopathol. 2021 Mar-Apr;10(2):231-238. doi: 10.1016/j.jasc.2020.08.009. 
      Epub 2020 Aug 25.