PMID- 32950828
OWN - NLM
STAT- MEDLINE
DCOM- 20210730
LR  - 20210730
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 212
DP  - 2020 Nov
TI  - Flavonoids ameliorate aluminum chloride-induced learning and memory impairments 
      via suppression of apoptosis and oxidative stress in rats.
PG  - 111252
LID - S0162-0134(20)30280-4 [pii]
LID - 10.1016/j.jinorgbio.2020.111252 [doi]
AB  - The study was to investigate the effects of flavonoids (rutin, puerarin, and 
      silymarin) on learning and memory function in rats exposed to aluminum chloride 
      (AlCl(3)). Wistar rats were administered flavonoids at a dose of 
      100 mg/(kg.bw)/day or 200 mg/(kg.bw)/day after exposed to 281.40 mg/(kg.bw)/day 
      AlCl(3).6H(2)O. The results of Morris water maze suggested that rutin and 
      puerarin increased the frequency of crossing the platform and swimming time spent 
      in the target quadrant of AlCl(3)-induced rats significantly. Terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay 
      indicated that three flavonoids could alleviate apoptosis of hippocampal neurons 
      induced by AlCl(3). Real time-PCR and western blot suggested that rutin, puerarin 
      and 100 mg/(kg.bw)/day silymarin could decrease the AlCl(3)-induced high 
      expression of Bcl-2 associated X protein (Bax) mRNA and protein in hippocampus, 
      but the expression of B cell lymphoma/leukemia-2 (Bcl-2) mRNA and protein was not 
      significantly different among groups. Flavonoids could up regulate the low 
      expression of autophagy related proteins (Beclin 1 (Bcl-2-interacting protein 
      with a coiled-coil domain 1) and LC3 (microtubule-associated protein 1 light 
      chain 3)) caused by AlCl(3) exposure. Flavonoids could also adjust the change in 
      adenosine triphosphatase, superoxide dismutase, glutathione peroxidase and 
      malondialdehyde induced by intake of AlCl(3). The results of inductively coupled 
      plasma atomic emission spectroscopy (ICP-AES) suggested that flavonoids could 
      effectively reduce the high Al level in brain and serum of AlCl(3) exposed rats. 
      In conclusion, three flavonoids may improve learning and memory function by 
      inhibiting excessive apoptosis and oxidative stress in AlCl(3) exposed rats.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Li, Shuling
AU  - Li S
AD  - Department of Hygiene Detection, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Zhang, Qiongyao
AU  - Zhang Q
AD  - Department of Hygiene Detection, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Ding, Yun
AU  - Ding Y
AD  - Department of Hygiene Detection, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Hygiene Detection, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China.
FAU - Liu, Ping
AU  - Liu P
AD  - Department of Hygiene Detection, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: 
      liupingp@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200913
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Flavonoids)
RN  - 3CYT62D3GA (Aluminum Chloride)
SB  - IM
MH  - Aluminum Chloride/*toxicity
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/administration & dosage/pharmacology/*therapeutic use
MH  - Hippocampus/cytology/drug effects/metabolism
MH  - Learning Disabilities/chemically induced/*drug therapy/metabolism
MH  - Male
MH  - Memory Disorders/chemically induced/*drug therapy/metabolism
MH  - Neurons/drug effects
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Aluminum
OT  - Antioxidant
OT  - Apoptosis
OT  - Flavonoids
OT  - Learning and memory function
EDAT- 2020/09/21 06:00
MHDA- 2021/07/31 06:00
CRDT- 2020/09/20 20:31
PHST- 2020/05/04 00:00 [received]
PHST- 2020/08/31 00:00 [revised]
PHST- 2020/09/06 00:00 [accepted]
PHST- 2020/09/21 06:00 [pubmed]
PHST- 2021/07/31 06:00 [medline]
PHST- 2020/09/20 20:31 [entrez]
AID - S0162-0134(20)30280-4 [pii]
AID - 10.1016/j.jinorgbio.2020.111252 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2020 Nov;212:111252. doi: 10.1016/j.jinorgbio.2020.111252. Epub 
      2020 Sep 13.