PMID- 32950903
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 28
DP  - 2020
TI  - Altered dynamic effective connectivity of the default mode network in newly 
      diagnosed drug-naive juvenile myoclonic epilepsy.
PG  - 102431
LID - S2213-1582(20)30268-0 [pii]
LID - 10.1016/j.nicl.2020.102431 [doi]
LID - 102431
AB  - Juvenile myoclonic epilepsy (JME) has been repeatedly revealed to be associated 
      with brain dysconnectivity in the default mode network (DMN). However, the 
      implicit assumption of stationary and nondirectional functional connectivity (FC) 
      in most previous resting-state fMRI studies raises an open question of 
      JME-related aberrations in dynamic causal properties of FC. Here, we introduces 
      an empirical method incorporating sliding-window approach and a multivariate 
      Granger causality analysis to investigate, for the first time, the reorganization 
      of dynamic effective connectivity (DEC) in DMN for patients with JME. DEC was 
      obtained from resting-state fMRI of 34 patients with newly diagnosed and 
      drug-naive JME and 34 matched controls. Through clustering analysis, we found two 
      distinct states that characterize the DEC patterns (i.e., a less frequent, 
      strongly connected state (State 1) and a more frequent, weakly connected state 
      (State 2)). Patients showed altered ECs within DMN subnetworks in the State 2, 
      whereas abnormal ECs between DMN subnetworks were found in the State 1. 
      Furthermore, we observed that the causal influence flows of the medial prefrontal 
      cortex and angular gyrus were altered in a manner of state specificity, and 
      associated with disease severity of patients. Overall, our findings extend the 
      dysconnectivity hypothesis in JME from static to dynamic causal FC and 
      demonstrate that aberrant DEC may underlie abnormal brain function in JME at 
      early phase of illness.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, Zhejiang University, Zhejiang, China.
FAU - Liu, Guangyao
AU  - Liu G
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Zheng, Weihao
AU  - Zheng W
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, Zhejiang University, Zhejiang, China.
FAU - Shi, Jie
AU  - Shi J
AD  - School of Information Science and Engineering, Lanzhou University, Lanzhou, 
      China.
FAU - Liu, Hong
AU  - Liu H
AD  - Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 
      China.
FAU - Sun, Yu
AU  - Sun Y
AD  - Key Laboratory for Biomedical Engineering of Ministry of Education, Department of 
      Biomedical Engineering, Zhejiang University, Zhejiang, China; Department of 
      Radiology, Children's Hospital, Zhejiang University School of Medicine, National 
      Clinical Research Center for Child Health, Zhejiang, China. Electronic address: 
      yusun@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200911
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Brain/diagnostic imaging
MH  - Brain Mapping
MH  - Default Mode Network
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Myoclonic Epilepsy, Juvenile/diagnostic imaging
MH  - *Pharmaceutical Preparations
PMC - PMC7509229
OTO - NOTNLM
OT  - Default mode network
OT  - Dynamic effective connectivity
OT  - Juvenile myoclonic epilepsy
OT  - Newly diagnosed drug-naive
EDAT- 2020/09/21 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/09/11
CRDT- 2020/09/20 20:34
PHST- 2020/06/18 00:00 [received]
PHST- 2020/08/08 00:00 [revised]
PHST- 2020/09/08 00:00 [accepted]
PHST- 2020/09/21 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/09/20 20:34 [entrez]
PHST- 2020/09/11 00:00 [pmc-release]
AID - S2213-1582(20)30268-0 [pii]
AID - 102431 [pii]
AID - 10.1016/j.nicl.2020.102431 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2020;28:102431. doi: 10.1016/j.nicl.2020.102431. Epub 2020 Sep 
      11.