PMID- 32952071 OWN - NLM STAT- MEDLINE DCOM- 20210901 LR - 20211110 IS - 1878-3562 (Electronic) IS - 1590-8658 (Linking) VI - 52 IP - 12 DP - 2020 Dec TI - Italian Clinical Practice Guidelines on Cholangiocarcinoma - Part II: Treatment. PG - 1430-1442 LID - S1590-8658(20)30449-7 [pii] LID - 10.1016/j.dld.2020.08.030 [doi] AB - Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements. CI - Copyright (c) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. CN - Cholangiocarcinoma Working Group LA - eng PT - Journal Article PT - Practice Guideline DEP - 20200918 PL - Netherlands TA - Dig Liver Dis JT - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JID - 100958385 SB - IM CIN - Dig Liver Dis. 2020 Dec;52(12):1428-1429. PMID: 33248542 MH - Bile Duct Neoplasms/pathology/*therapy MH - Bile Ducts, Intrahepatic/*pathology MH - Chemoradiotherapy MH - Cholangiocarcinoma/*therapy MH - Combined Modality Therapy MH - Humans MH - Immunotherapy MH - Italy MH - Liver Transplantation MH - Patient Selection MH - Radiotherapy, Adjuvant MH - Surgical Procedures, Operative OTO - NOTNLM OT - Distal cholangiocarcinoma OT - Intrahepatic cholangiocarcinoma OT - Liver transplantation OT - Locoregional treatments OT - Perihilar cholangiocarcinoma OT - Surgery OT - Target therapies COIS- Declaration of Competing Interest None. FIR - Alvaro, Domenico IR - Alvaro D IRAD- Chair, AISF and SIGE, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. Electronic address: domenico.alvaro@uniroma1.it. FIR - Hassan, Cesare IR - Hassan C IRAD- Co-Chair, Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy. FIR - Cardinale, Vincenzo IR - Cardinale V IRAD- AISF, SIGE; Department of Medical- Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy. FIR - Carpino, Guido IR - Carpino G IRAD- AISF; Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy. FIR - Fabris, Luca IR - Fabris L IRAD- AISF, SIGE; Department of Molecular Medicine, Azienda Ospedaliera/Universitadi Padova, Padova, Italy. FIR - Gringeri, Enrico IR - Gringeri E IRAD- SITO; Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gas- troenterology, DISCOG, Padova, Italy. FIR - Granata, Vincenza IR - Granata V IRAD- SIRM; Division of Radiology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Napoli, Italy. FIR - Mutignani, Massimiliano IR - Mutignani M IRAD- SIGE; Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy. FIR - Morement, Helen IR - Morement H IRAD- AMMF - The Cholangiocarcinoma Charity, United Kingdom. FIR - Giuliante, Felice IR - Giuliante F IRAD- SIC; Unit of Hepatobiliary Surgery, Fon- dazione Policlinico Universitario A. Gemelli IRCCS, Universita Cattolica Del Sacro Cuore, Rome, Italy. FIR - Guglielmi, Alfredo IR - Guglielmi A IRAD- IT-IHPBA; Department of Surgery, Division of General and Hepatobiliary Surgery, G.B. Rossi University Hospital, University of Verona, Verona, Italy. FIR - Ridola, Lorenzo IR - Ridola L IRAD- AISF, SIGE; Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. FIR - Tonini, Giuseppe IR - Tonini G IRAD- Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy. FIR - Marzioni, Marco IR - Marzioni M IRAD- Department of Gastroenterology and Hepatology, Universita Politecnica delle Marche, Ancona, Italy. FIR - Grazi, Gianluca IR - Grazi G IRAD- Division of Hepatopancreatobiliary Surgery, Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, Italy. FIR - Guido, Maria IR - Guido M IRAD- Department of Medicine-DIMED, University of Padova, Italy. FIR - Di Giulio, Emilio IR - Di Giulio E IRAD- Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy. FIR - Pantano, Francesco IR - Pantano F IRAD- Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy. FIR - Venere, Rosanna IR - Venere R IRAD- Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. FIR - Bragazzi, Maria Consiglia IR - Bragazzi MC IRAD- Gastroenterology Unit, Santa Maria Goretti Hospital, Latina, Italy. FIR - Biancanello, Francesca IR - Biancanello F IRAD- Department of Medical-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy. FIR - Faccioli, Jessica IR - Faccioli J IRAD- Department of Translational and Precision Medicine, "Sapienza" University of Rome, Italy. FIR - Giannetti, Aurora IR - Giannetti A IRAD- Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy. FIR - Cintolo, Marcello IR - Cintolo M IRAD- Digestive Endoscopy Unit, ASST Niguarda, Milan, Italy. FIR - Di Giunta, Michela IR - Di Giunta M IRAD- Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy. FIR - Gambato, Martina IR - Gambato M IRAD- Multivisceral Transplant Unit and Gastroenterology, Department of Surgery Oncology and Gastroenterology, DISCOG, Padova, Italy. FIR - Lasagni, Alberto IR - Lasagni A IRAD- Department of Molecular Medicine, Azienda Ospedaliera/Universitadi Padova, Italy. FIR - Izzo, Francesco IR - Izzo F IRAD- Division of Hepatobiliary Surgery, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy. FIR - Avallone, Antonio IR - Avallone A IRAD- Division of Abdominal Oncology, Istituto Nazionale dei Tumori, IRCCS, Fondazione Pascale, Naples, Italy. FIR - Banales, Jesus IR - Banales J IRAD- Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain. FIR - Rossi, Massimo IR - Rossi M IRAD- Hepato-bilio-pancreatic and Liver Transplant Unit, Department of Surgery, "Sapienza" University of Rome, Italy. FIR - Catalano, Carlo IR - Catalano C IRAD- Department of Radiological, Oncological and Anatomopathological Sciences, "Sapienza" University of Rome, Rome, Italy. FIR - Laghi, Andrea IR - Laghi A IRAD- Department of Medical-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy. FIR - D'amati, Giulia IR - D'amati G IRAD- Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy. FIR - Mancino, Maria Grazia IR - Mancino MG IRAD- UOC Gastroenterologia ed Endoscopia Digestiva AORN Sant'Anna e San Sebastiano, Caserta, Italy. FIR - Ridola, Lorenzo IR - Ridola L IRAD- Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy. EDAT- 2020/09/22 06:00 MHDA- 2021/09/02 06:00 CRDT- 2020/09/21 05:37 PHST- 2020/07/22 00:00 [received] PHST- 2020/08/17 00:00 [revised] PHST- 2020/08/17 00:00 [accepted] PHST- 2020/09/22 06:00 [pubmed] PHST- 2021/09/02 06:00 [medline] PHST- 2020/09/21 05:37 [entrez] AID - S1590-8658(20)30449-7 [pii] AID - 10.1016/j.dld.2020.08.030 [doi] PST - ppublish SO - Dig Liver Dis. 2020 Dec;52(12):1430-1442. doi: 10.1016/j.dld.2020.08.030. Epub 2020 Sep 18.