PMID- 32952667
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2221-285X (Electronic)
IS  - 1818-0876 (Print)
IS  - 1818-0876 (Linking)
VI  - 15
IP  - 4
DP  - 2020 Jul
TI  - Tumor microenvironment responsive drug delivery systems.
PG  - 416-448
LID - 10.1016/j.ajps.2019.08.003 [doi]
AB  - Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as 
      unsatisfied systemic circulation, low targeting efficiency, poor tumoral 
      penetration, and uncontrolled drug release. Recently, tumor cellular 
      molecules-triggered DDSs have aroused great interests in addressing such 
      dilemmas. With the introduction of several additional functionalities, the 
      properties of these smart DDSs including size, surface charge and ligand exposure 
      can response to different tumor microenvironments for a more efficient tumor 
      targeting, and eventually achieve desired drug release for an optimized 
      therapeutic efficiency. This review highlights the recent research progresses on 
      smart tumor environment responsive drug delivery systems for targeted drug 
      delivery. Dynamic targeting strategies and functional moieties sensitive to a 
      variety of tumor cellular stimuli, including pH, glutathione, 
      adenosine-triphosphate, reactive oxygen species, enzyme and inflammatory factors 
      are summarized. Special emphasis of this review is placed on their responsive 
      mechanisms, drug loading models, drawbacks and merits. Several typical 
      multi-stimuli responsive DDSs are listed. And the main challenges and potential 
      future development are discussed.
CI  - (c) 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V.
FAU - He, Qunye
AU  - He Q
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
FAU - Yan, Jianhua
AU  - Yan J
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
FAU - Cai, Shundong
AU  - Cai S
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
FAU - Xiong, Hongjie
AU  - Xiong H
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
FAU - Liu, Yanfei
AU  - Liu Y
AD  - School of Chemistry and Chemical Engineering, Central South University, Changsha 
      410083, China.
FAU - Peng, Dongming
AU  - Peng D
AD  - School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
FAU - Mo, Miao
AU  - Mo M
AD  - Department of Urology, Xiangya Hospital, Central South University, Changsha 
      410008, China.
FAU - Liu, Zhenbao
AU  - Liu Z
AD  - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 
      410013, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190926
PL  - Netherlands
TA  - Asian J Pharm Sci
JT  - Asian journal of pharmaceutical sciences
JID - 101535338
PMC - PMC7486519
OTO - NOTNLM
OT  - Cancer therapy
OT  - Controlled release
OT  - Drug delivery system
OT  - Dynamic targeting
OT  - Stimuli responsive
COIS- The authors report no conflicts of interest. The authors alone are responsible 
      for the content and writing of this article.
EDAT- 2020/09/22 06:00
MHDA- 2020/09/22 06:01
PMCR- 2019/09/26
CRDT- 2020/09/21 06:06
PHST- 2019/04/29 00:00 [received]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/08/21 00:00 [accepted]
PHST- 2020/09/21 06:06 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/09/22 06:01 [medline]
PHST- 2019/09/26 00:00 [pmc-release]
AID - S1818-0876(19)30471-4 [pii]
AID - 10.1016/j.ajps.2019.08.003 [doi]
PST - ppublish
SO  - Asian J Pharm Sci. 2020 Jul;15(4):416-448. doi: 10.1016/j.ajps.2019.08.003. Epub 
      2019 Sep 26.