PMID- 32953413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 23
IP  - 1
DP  - 2020 Jun
TI  - Association of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with 
      Body Mass Index, Fasting Glucose Levels and Lipid Status in Adolescents.
PG  - 77-82
LID - 10.2478/bjmg-2020-0004 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has an important role in energy balance. 
      It suppresses food intake, reduces hepatic glucose production and converts white 
      fat into brown fat in adipose tissue, leading to energy dissipation, lowered 
      blood glucose and a lean phenotype. Studies have shown that the single nucleotide 
      polymorphism (SNP) Val66Met within BDNF may be associated with obesity, insulin 
      sensitivity, type 2 diabetes mellitus (T2DM) and dyslipidemia. The objective of 
      the study was to investigate the association of the Val66Met polymorphism with 
      body mass index (BMI), fasting glucose levels and lipid profile in Serbian 
      adolescents. The study included 308 randomly selected healthy adolescents, 153 
      (49.68%) boys and 155 girls (50.32%), 15 years of age. Data including age, 
      gender, height, weight, lipid profile and fasting glucose were recorded. 
      Genotyping was performed by the polymerase chain reaction-restriction fragment 
      length polymorphism (PCR-RFLP) method. No association of this polymorphism was 
      found with BMI and lipid profile. However, significant association was observed 
      between this polymorphism and fasting blood glucose (FBG). Carriers of a Val/Val 
      genotype had significantly higher mean values of fasting glucose level compared 
      to carriers of Val/ Met and Met/Met genotypes (p = 0.01). To confirm these 
      results multiple linear regression analysis was performed. Body mass index and 
      gender were taken as covariates. Carriers of the Val/Val genotype had 
      significantly higher levels of FBG (beta = -0.152, p = 0.02). A statistically 
      significant association between BMI and glucose level was also observed (beta = 
      0.124,p = 0.033). This polymorphism could be associated with fasting glucose 
      level in Serbian adolescents, thus further research would be of great interest to 
      validate these results.
CI  - (c) 2020 Vidovic V, Maksimovic N, Novakovic I, Damnjanovic T, Jekic B, Vidovic S, 
      Majkic Singh N, Stamenkovic-Radak M, Nikolic D, Marisavljevic D, published by 
      Sciendo.
FAU - Vidovic, V
AU  - Vidovic V
AD  - Department of Human Genetics, Faculty of Medicine, University of Banja Luka, 
      Banja Luka, Bosnia and Herzegovina.
FAU - Maksimovic, N
AU  - Maksimovic N
AD  - Institute of Human Genetics, Faculty of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Novakovic, I
AU  - Novakovic I
AD  - Institute of Human Genetics, Faculty of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Damnjanovic, T
AU  - Damnjanovic T
AD  - Institute of Human Genetics, Faculty of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Jekic, B
AU  - Jekic B
AD  - Institute of Human Genetics, Faculty of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Vidovic, S
AU  - Vidovic S
AD  - Department of Human Genetics, Faculty of Medicine, University of Banja Luka, 
      Banja Luka, Bosnia and Herzegovina.
FAU - Majkic Singh, N
AU  - Majkic Singh N
AD  - Society of Medical Biochemists, Belgrade, Serbia.
FAU - Stamenkovic-Radak, M
AU  - Stamenkovic-Radak M
AD  - Department of Genetics and Evolution, Faculty of Biology, University of Belgrade, 
      Belgrade, Serbia.
FAU - Nikolic, D
AU  - Nikolic D
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      University of Belgrade, University Children's Hospital, Belgrade, Serbia.
FAU - Marisavljevic, D
AU  - Marisavljevic D
AD  - Department of Hematology, Medical Center Beza-nijska Kosa, Faculty of Medicine, 
      University of Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20200826
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC7474215
OTO - NOTNLM
OT  - Body mass index (BMI)
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Fasting glucose level
OT  - Gene polymorphism
OT  - Lipid profile
EDAT- 2020/09/22 06:00
MHDA- 2020/09/22 06:01
PMCR- 2020/08/26
CRDT- 2020/09/21 06:13
PHST- 2020/09/21 06:13 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/09/22 06:01 [medline]
PHST- 2020/08/26 00:00 [pmc-release]
AID - bjmg-2020-0004 [pii]
AID - 10.2478/bjmg-2020-0004 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2020 Aug 26;23(1):77-82. doi: 10.2478/bjmg-2020-0004. 
      eCollection 2020 Jun.