PMID- 32954499
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20221207
IS  - 1558-9307 (Electronic)
IS  - 0024-4201 (Linking)
VI  - 56
IP  - 1
DP  - 2021 Jan
TI  - A Cross-sectional Study on the Relationship Between Homocysteine and Lipid 
      Profiles Among Chinese Population from Hunan.
PG  - 93-100
LID - 10.1002/lipd.12279 [doi]
AB  - Previous studies have explored the relationship between homocystein (Hcy) and 
      lipid profiles. However, the results from these studies have been inconsistent. 
      The current study investigated the correlation between Hcy and lipid profiles in 
      Chinese community-based population. The participants were composed of 4012 
      Chinese people aged 30-92 years old, who were recruited from rural and urban 
      communities in the Hunan Province. Non-parametric test and logistic regression 
      were used to examine the distribution of Hcy and lipid profiles (triglyceride 
      [TG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], 
      high-density lipoprotein cholesterol [HDL-C]) and the relationship between them. 
      The median age of subjects was 54.50 years old, and 40.98% were male. Median Hcy 
      was 13.20 mumol/L, and 35.39% had hyperhomocysteinemia (HHcy). Median TG was 
      1.51 mmol/L, TC was 4.77 mmol/L, LDL-C was 2.62 mmol/L, and HDL-C was 
      1.27 mmol/L. In multivariable logistic regression analysis, HHcy was associated 
      with high levels of TG (OR(male) = 2.240, p < 0.001; OR(female) = 2.539, 
      p < 0.001), TC (OR(male) = 2.237, p < 0.001; OR(female) = 2.202, p < 0.001), and 
      LDL-C (OR(male) = 1.413, p = 0.010; OR(female) = 1.617, p < 0.001) in the 
      different sexes population and low level of HDL-C in females (OR = 1.326, p = 
      0.023) after adjusting for confounders. HHcy was independently associated with an 
      increasing risk of low HDL-C among females. The regression analysis showed that 
      HHcy was also associated with hypertriglyceridemia, hypercholesterolemia, and 
      high level of LDL-C in males and females from Chinese community-based population, 
      which provides a basis for the treatment and prevention of abnormal lipid 
      metabolism.
CI  - (c) 2020 AOCS.
FAU - Niu, Xiaona
AU  - Niu X
AUID- ORCID: 0000-0003-3469-3637
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha, China.
FAU - Chen, Jian
AU  - Chen J
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
FAU - Wang, Jia
AU  - Wang J
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
FAU - Li, Jing
AU  - Li J
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
FAU - Zeng, Dan
AU  - Zeng D
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
FAU - Wang, Shuling
AU  - Wang S
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
FAU - Hong, Xiuqin
AU  - Hong X
AD  - First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's 
      Hospital, Changsha, China.
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200921
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Lipids)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*analysis
MH  - Humans
MH  - Lipids/*analysis
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - High-density lipoprotein (HDL-C)
OT  - Homocysteine (Hcy)
OT  - Low-density lipoprotein cholesterol (LDL-C)
OT  - Total cholesterol (TC)
OT  - Triglyceride (TG)
EDAT- 2020/09/22 06:00
MHDA- 2021/09/28 06:00
CRDT- 2020/09/21 06:27
PHST- 2020/05/26 00:00 [received]
PHST- 2020/08/05 00:00 [revised]
PHST- 2020/08/12 00:00 [accepted]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2020/09/21 06:27 [entrez]
AID - 10.1002/lipd.12279 [doi]
PST - ppublish
SO  - Lipids. 2021 Jan;56(1):93-100. doi: 10.1002/lipd.12279. Epub 2020 Sep 21.