PMID- 32954823
OWN - NLM
STAT- MEDLINE
DCOM- 20201223
LR  - 20201223
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Linking)
VI  - 319
IP  - 6
DP  - 2020 Dec 1
TI  - Vascular endothelial growth factor B promotes transendothelial fatty acid 
      transport into skeletal muscle via histone modifications during catch-up growth.
PG  - E1031-E1043
LID - 10.1152/ajpendo.00090.2020 [doi]
AB  - Caloric restriction (CR) followed by refeeding, a phenomenon known as catch-up 
      growth (CUG), results in excessive lipid deposition and insulin resistance in 
      skeletal muscle, but the underlying mechanisms remain elusive. Recent reports 
      have suggested that vascular endothelial growth factor B (VEGF-B) controls muscle 
      lipid accumulation by regulating endothelial fatty acid transport. Here, we found 
      continuous activation of VEGF-B signaling and increased lipid uptake in skeletal 
      muscle from CR to refeeding, as well as increased lipid deposition and impaired 
      insulin sensitivity after refeeding in the skeletal muscle of CUG rodents. 
      Inhibiting VEGF-B signaling reduced fatty acid uptake in and transport across 
      endothelial cells. Knockdown of Vegfb in the tibialis anterior (TA) muscle of CUG 
      mice significantly attenuated muscle lipid accumulation and ameliorated muscle 
      insulin sensitivity by decreasing lipid uptake. Furthermore, we showed that 
      aberrant histone methylation (H3K9me1) and acetylation (H3K14ac and H3K18ac) at 
      the Vegfb promoter might be the main cause of persistent VEGF-B upregulation in 
      skeletal muscle during CUG. Modifying these aberrant loci using their related 
      enzymes [PHD finger protein 2 (PHF2) or E1A binding protein p300 (p300)] could 
      regulate VEGF-B expression in vitro. Collectively, our findings indicate that 
      VEGF-B can promote transendothelial lipid transport and lead to lipid 
      overaccumulation and insulin resistance in skeletal muscle during CUG, which 
      might be mediated by histone methylation and acetylation.
FAU - Lu, Xiaodan
AU  - Lu X
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Hu, Shengqing
AU  - Hu S
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Liao, Yunfei
AU  - Liao Y
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Zheng, Juan
AU  - Zheng J
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Zeng, Tianshu
AU  - Zeng T
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Zhong, Xueyu
AU  - Zhong X
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Liu, Geng
AU  - Liu G
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Gou, Luoning
AU  - Gou L
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
FAU - Chen, Lulu
AU  - Chen L
AD  - Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, 
      Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200921
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Fatty Acids)
RN  - 0 (Histones)
RN  - 0 (Vascular Endothelial Growth Factor B)
SB  - IM
MH  - Animals
MH  - Caloric Restriction/adverse effects
MH  - Endothelial Cells/*metabolism
MH  - Fatty Acids/*metabolism
MH  - Gene Knockdown Techniques
MH  - Growth/genetics/*physiology
MH  - Histone Code/genetics
MH  - Histones/*metabolism
MH  - Lipid Metabolism/genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Muscle, Skeletal/*metabolism
MH  - Protein Processing, Post-Translational/*genetics
MH  - Vascular Endothelial Growth Factor B/genetics/*physiology
OTO - NOTNLM
OT  - catch-up growth
OT  - epigenetics
OT  - skeletal muscle insulin resistance
OT  - transendothelial fatty acid transport
OT  - vascular endothelial growth factor B
EDAT- 2020/09/22 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/09/21 08:40
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/09/21 08:40 [entrez]
AID - 10.1152/ajpendo.00090.2020 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2020 Dec 1;319(6):E1031-E1043. doi: 
      10.1152/ajpendo.00090.2020. Epub 2020 Sep 21.