PMID- 32955964
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20221207
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 24
IP  - 5
DP  - 2021 May
TI  - Administration of Herbarium Mixture (Guazuma ulmifolia/Tecoma stans) on Metabolic 
      Profile in Type 2 Diabetes Mellitus Patients: A Randomized, Double-Blind, 
      Placebo-Controlled Trial.
PG  - 527-532
LID - 10.1089/jmf.2020.0082 [doi]
AB  - The use of herbarium mixture has been empirical, and the properties are not yet 
      known. The aim of this study was to evaluate the effect of oral administration of 
      herbarium mixture (Guazuma ulmifolia [G. ulmifolia]/Tecoma stans [T. stans]) on 
      metabolic profile in patients with type 2 diabetes mellitus (T2DM). A randomized, 
      double-blind, placebo-controlled, clinical trial was carried out in 40 patients 
      with T2DM. They were between 40 and 65 years of age, with body mass index (BMI) 
      between 25.0 and 34.9 kg/m(2) and HbA1c >7.0%. BMI, waist circumference, fasting 
      glucose, HbA1c, lipids, kidney, and liver function were measured. The patients 
      were randomly assigned to receive the herbarium mixture (G. ulmifolia/T. stans) 
      400 mg before each meal, or placebo for 90 days. Herbarium mixture group showed 
      decreased waist circumference (99 +/- 14 vs. 98 +/- 15 cm; P = .019), fasting glucose 
      (12.0 +/- 5.7 vs. 10.3 +/- 5.1 mM; P = .019), and HbA1c (9.9% +/- 2.7% vs. 8.9% +/- 2.5%, 
      P = .002). In conclusion, the administration of herbarium mixture (G. 
      ulmifolia/T. stans) improved the glycemic profile in patients with T2DM. 
      ClinicalTrial registration: NCT03313856 ClinicalTrials.gov.
FAU - Pascoe-Gonzalez, Sara
AU  - Pascoe-Gonzalez S
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
FAU - Ramos-Zavala, Maria Guadalupe
AU  - Ramos-Zavala MG
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
FAU - Buenrostro Ahued, Miguel Angel
AU  - Buenrostro Ahued MA
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
FAU - Hernandez-Gonzalez, Sandra Ofelia
AU  - Hernandez-Gonzalez SO
AD  - Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical 
      Unit of High Specialty, West National Medical Center, Mexican Institute of Social 
      Security, Guadalajara, Mexico.
FAU - Cardona-Munoz, Ernesto German
AU  - Cardona-Munoz EG
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
FAU - Garcia-Benavides, Leonel
AU  - Garcia-Benavides L
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
FAU - Grover-Paez, Fernando
AU  - Grover-Paez F
AD  - Department of Physiology, Health Science University Center, Institute of 
      Experimental and Clinical Therapeutics, University of Guadalajara, Guadalajara, 
      Mexico.
LA  - eng
SI  - ClinicalTrials.gov/NCT03313856
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200921
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - *Bignoniaceae/metabolism
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Double-Blind Method
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents
MH  - Metabolome
OTO - NOTNLM
OT  - G. ulmifolia
OT  - HbA1c
OT  - T. stans
OT  - glucose
OT  - type 2 diabetes
EDAT- 2020/09/22 06:00
MHDA- 2021/05/22 06:00
CRDT- 2020/09/21 17:12
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2020/09/21 17:12 [entrez]
AID - 10.1089/jmf.2020.0082 [doi]
PST - ppublish
SO  - J Med Food. 2021 May;24(5):527-532. doi: 10.1089/jmf.2020.0082. Epub 2020 Sep 21.