PMID- 32956816
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20221028
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 27
IP  - 3
DP  - 2021 Mar
TI  - Cognition, Physical Function, and Quality of Life in Older Patients With Acute 
      Decompensated Heart Failure.
PG  - 286-294
LID - S1071-9164(20)30954-4 [pii]
LID - 10.1016/j.cardfail.2020.09.007 [doi]
AB  - BACKGROUND: Older adults with acute decompensated heart failure have persistently 
      poor clinical outcomes. Cognitive impairment (CI) may be a contributing factor. 
      However, the prevalence of CI and the relationship of cognition with other 
      patient-centered factors such a physical function and quality of life (QOL) that 
      also may contribute to poor outcomes are incompletely understood. METHODS AND 
      RESULTS: Older (>/=60 years) hospitalized patients with acute decompensated heart 
      failure were assessed for cognition (Montreal Cognitive Assessment [MoCA]), 
      physical function (Short Physical Performance Battery [SPPB], 6-minute walk 
      distance [6MWD]), and QOL (Kansas City Cardiomyopathy Questionnaire, Short 
      Form-12). Among patients (N = 198, 72.1 +/- 7.6 years), 78% screened positive for 
      CI (MoCA of <26) despite rare medical record documentation (2%). Participants 
      also had severely diminished physical function (SPPB 6.0 +/- 2.5 units, 6MWD 186 +/- 
      100 m) and QOL (scores of <50). MoCA positively related to SPPB (ss = 0.47, P < 
      .001), 6MWD ss = 0.01, P = .006) and inversely related to Kansas City 
      Cardiomyopathy Questionnaire Overall Score (ss = -0.05, P < .002) and Short 
      Form-12 Physical Component Score (ss = -0.09, P = .006). MoCA was a small but 
      significant predictor of the results on the SPPB, 6MWD, and Kansas City 
      Cardiomyopathy Questionnaire. CONCLUSIONS: Among older hospitalized patients with 
      acute decompensated heart failure, CI is highly prevalent, is underrecognized 
      clinically, and is associated with severe physical dysfunction and poor QOL. 
      Formal screening may reduce adverse events by identifying patients who may 
      require more tailored care.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Pastva, Amy M
AU  - Pastva AM
AD  - Department of Orthopaedic Surgery, Division of Physical Therapy, and Duke Claude 
      D. Pepper Older Americans Independence Center, Duke University School of 
      Medicine, Durham, NC. Electronic address: amy.pastva@duke.edu.
FAU - Hugenschmidt, Christina E
AU  - Hugenschmidt CE
AD  - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, 
      Wake Forest School of Medicine, Winston-Salem, NC.
FAU - Kitzman, Dalane W
AU  - Kitzman DW
AD  - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, 
      Wake Forest School of Medicine, Winston-Salem, NC; Department of Internal 
      Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 
      Winston-Salem, NC.
FAU - Nelson, M Benjamin
AU  - Nelson MB
AD  - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, 
      Wake Forest School of Medicine, Winston-Salem, NC.
FAU - Brenes, Gretchen A
AU  - Brenes GA
AD  - Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, 
      Wake Forest School of Medicine, Winston-Salem, NC; Department of Social Sciences 
      and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC.
FAU - Reeves, Gordon R
AU  - Reeves GR
AD  - Department of Medicine, Novant Health, Charlotte, NC.
FAU - Mentz, Robert J
AU  - Mentz RJ
AD  - Division of Cardiology, Duke University School of Medicine, Durham, NC.
FAU - Whellan, David J
AU  - Whellan DJ
AD  - Department of Medicine, Thomas Jefferson University, Philadelphia, PA.
FAU - Chen, Haiying
AU  - Chen H
AD  - Department of Biostatistics and Data Science, Wake Forest School of Medicine, 
      Winston-Salem, NC.
FAU - Duncan, Pamela W
AU  - Duncan PW
AD  - Department of Neurology and Sticht Center on Aging Gerontology and Geriatric 
      Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
LA  - eng
GR  - R37 AG018915/AG/NIA NIH HHS/United States
GR  - R01 AG018915/AG/NIA NIH HHS/United States
GR  - P30 AG049638/AG/NIA NIH HHS/United States
GR  - U24 AG059624/AG/NIA NIH HHS/United States
GR  - U01 HL125511/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001420/TR/NCATS NIH HHS/United States
GR  - R01 AG045551/AG/NIA NIH HHS/United States
GR  - P30 AG028716/AG/NIA NIH HHS/United States
GR  - P30 AG021332/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20200918
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
CIN - J Card Fail. 2021 Mar;27(3):295-296. PMID: 33632392
MH  - Aged
MH  - Cognition
MH  - *Cognitive Dysfunction/diagnosis/epidemiology
MH  - *Heart Failure/diagnosis/epidemiology
MH  - Humans
MH  - Prevalence
MH  - Quality of Life
PMC - PMC7914148
MID - NIHMS1631943
OTO - NOTNLM
OT  - Acute decompensated heart failure
OT  - cognitive function
OT  - physical function
OT  - quality of life
EDAT- 2020/09/22 06:00
MHDA- 2021/09/18 06:00
PMCR- 2022/03/01
CRDT- 2020/09/21 20:12
PHST- 2020/03/26 00:00 [received]
PHST- 2020/08/25 00:00 [revised]
PHST- 2020/09/14 00:00 [accepted]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/09/21 20:12 [entrez]
PHST- 2022/03/01 00:00 [pmc-release]
AID - S1071-9164(20)30954-4 [pii]
AID - 10.1016/j.cardfail.2020.09.007 [doi]
PST - ppublish
SO  - J Card Fail. 2021 Mar;27(3):286-294. doi: 10.1016/j.cardfail.2020.09.007. Epub 
      2020 Sep 18.