PMID- 32957121
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20211001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 50
IP  - 3
DP  - 2020 Sep 30
TI  - The effect of hyperbaric oxygen treatment on late radiation tissue injury after 
      breast cancer: A case-series of 67 patients.
PG  - 206-13
LID - 10.28920/dhm50.3.206-213 [doi]
AB  - INTRODUCTION: Late radiation tissue injury (LRTI) after breast cancer may benefit 
      from hyperbaric oxygen treatment (HBOT). This study aimed to report the LRTI 
      symptom scores up to 12 months after HBOT and identify risk factors for poor 
      scores. METHODS: A case-series of 67 patients who underwent a mean of 44 sessions 
      of HBOT was analysed. LRTI symptoms were scored at four time points using the 
      LENT-SOMA scale (Late Effects in Normal Tissues - Subjective, Objective, 
      Management, and Analytic), a visual analog scale for pain, and the range of 
      shoulder motion. RESULTS: Between starting HBOT and 12 months after HBOT 57 
      patients (85%) reported at least one point improvement in their LENT-SOMA score. 
      Median pain and fibrosis scores improved significantly between the start and end 
      of HBOT (P < 0.001), and remained stable three and 12 months after HBOT. The 
      median breast oedema score improved significantly 12 months after HBOT (P = 
      0.003). Median shoulder abduction increased significantly from 90 to 165 degrees 
      (P = 0.001) and median shoulder anteflexion increased significantly from 115 to 
      150 degrees (P = 0.004). Various risk factors were identified for poor scores 
      despite HBOT; the most common risk factor was a poor score at start of HBOT. 
      CONCLUSIONS: In this case-series, patients who underwent HBOT for LRTI after 
      breast cancer reported significant improvement in pain, fibrosis, oedema, and 
      shoulder movement. The improvement persisted up to 12 months after HBOT. A poor 
      score at the start of HBOT was predictive for a poor score 12 months after HBOT.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Spruijt, Nicole E
AU  - Spruijt NE
AD  - Da Vinci Clinic, Nieuwendijk 49, 5664HB Geldrop, the Netherlands.
AD  - Corresponding author: Dr Nicole E Spruijt, Da Vinci Clinic, Nieuwendijk 49, 
      5664HB Geldrop, the Netherlands, n.spruijt@davincikliniek.com.
FAU - van den Berg, Roy
AU  - van den Berg R
AD  - Da Vinci Clinic, Nieuwendijk 49, 5664HB Geldrop, the Netherlands.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Breast Neoplasms/radiotherapy
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Oxygen
MH  - *Radiation Injuries/therapy
MH  - Research Design
PMC - PMC7819722
OTO - NOTNLM
OT  - Hyperbaric medicine
OT  - Pain
OT  - Radiotherapy
OT  - Soft-tissue radionecrosis
COIS- Conflicts of interest and funding: nil
EDAT- 2020/09/22 06:00
MHDA- 2020/11/11 06:00
PMCR- 2021/09/30
CRDT- 2020/09/21 20:22
PHST- 2019/12/13 00:00 [received]
PHST- 2020/04/14 00:00 [accepted]
PHST- 2020/09/21 20:22 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.28920/dhm50.3.206-213 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2020 Sep 30;50(3):206-13. doi: 10.28920/dhm50.3.206-213.