PMID- 32957125
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20211001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 50
IP  - 3
DP  - 2020 Sep 30
TI  - Assessment of insulin sensitivity during hyperbaric oxygen treatment.
PG  - 238-243
LID - 10.28920/dhm50.3.238-243 [doi]
AB  - INTRODUCTION: Previous studies using a hyperinsulinaemic, euglycaemic glucose 
      clamp have demonstrated an increase in peripheral insulin sensitivity in men with 
      and without Type-2 diabetes mellitus on the third and thirtieth hyperbaric oxygen 
      treatment (HBOT) session. In two studies using different techniques for 
      assessment of insulin sensitivity, we investigated the onset and duration of this 
      insulin-sensitising effect of HBOT. METHODS: Men who were obese or overweight but 
      without diabetes were recruited. One study performed a hyperinsulinaemic 
      euglycaemic glucose clamp (80 mU.m(-2).min(-1)) at baseline and during the first 
      HBOT exposure (n = 9) at a pressure of 203 kPa. Data were analysed by paired 
      t-test. The other study assessed insulin sensitivity by a frequently sampled 
      intravenous glucose tolerance test (FSIGT) at three time points: baseline, during 
      the third HBOT and 24-hours post-HBOT (n = 9). Results were analysed by 
      repeated-measures ANOVA. RESULTS: There was a significant 23% increase in insulin 
      sensitivity by clamp measured during the first HBOT exposure. The FSIGT showed no 
      significant changes in insulin sensitivity. CONCLUSIONS: The hyperinsulinaemic, 
      euglycaemic glucose clamp demonstrated a significant increase in peripheral 
      insulin sensitivity during a single, 2-hour HBOT session in a group of men who 
      were obese or overweight but without diabetes. As an alternate technique for 
      assessing insulin sensitivity during HBOT, the FSIGT failed to show any changes 
      during the third HBOT and 24-hours later, however modification of the study 
      protocol should be considered.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Wilkinson, David
AU  - Wilkinson D
AD  - Hyperbaric Medicine Unit, Royal Adelaide Hospital, Adelaide, Australia.
AD  - Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
AD  - Corresponding author: Dr David Wilkinson, Hyperbaric Medicine Unit, Royal 
      Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia, 
      david.wilkinson@sa.gov.au.
FAU - Szekely, Suzy
AU  - Szekely S
AD  - Hyperbaric Medicine Unit, Royal Adelaide Hospital, Adelaide, Australia.
FAU - Gue, Brian
AU  - Gue B
AD  - Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
FAU - Tam, Charmaine S
AU  - Tam CS
AD  - Centre for Translational Data Science and Northern Clinical School, Sydney, 
      Australia.
FAU - Chapman, Ian
AU  - Chapman I
AD  - Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
FAU - Heilbronn, Leonie K
AU  - Heilbronn LK
AD  - Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Blood Glucose
MH  - Glucose Clamp Technique
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Insulin
MH  - *Insulin Resistance
MH  - Male
MH  - Oxygen
PMC - PMC7819732
OTO - NOTNLM
OT  - Endocrinology
OT  - Hyperbaric research
OT  - Metabolism
OT  - Obesity
OT  - Physiology
COIS- Conflicts of interest and funding The authors have no conflicts to declare. 
      Grants were provided by the Royal Adelaide Hospital Research Committee and 
      Australasian Diving and Hyperbaric Medicine Research Trust.
EDAT- 2020/09/22 06:00
MHDA- 2020/11/11 06:00
PMCR- 2021/09/30
CRDT- 2020/09/21 20:22
PHST- 2020/01/07 00:00 [received]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/09/21 20:22 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.28920/dhm50.3.238-243 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2020 Sep 30;50(3):238-243. doi: 10.28920/dhm50.3.238-243.