PMID- 32957127
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20211001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 50
IP  - 3
DP  - 2020 Sep 30
TI  - An observational trial to establish the effect of hyperbaric oxygen treatment on 
      pelvic late radiation tissue injury due to radiotherapy.
PG  - 250-255
LID - 10.28920/dhm50.3.250-255 [doi]
AB  - INTRODUCTION: Rates of pelvic cancer are growing globally with around half of 
      these patients receiving radiotherapy. In a small proportion, radiotherapy 
      results in significant late radiation tissue injury (LRTI) to surrounding tissue, 
      most commonly affecting the bladder and bowel mucosa. We conducted a combined 
      prospective and retrospective observational trial to establish the effectiveness 
      of hyperbaric oxygen treatment (HBOT) in improving the symptoms and signs of LRTI 
      in these patients. METHODS: Fifty-two patients were included after receiving 
      radiotherapy for cancers of the bowel, bladder, cervix, prostate or vulva. They 
      received HBOT at 203-243 kPa (2.0-2.4 atmospheres absolute (atm abs)) for 90 
      minutes with the median number of treatments being 30 (IQR 1). Late effects 
      normal tissues - subjective, objective, management, analytic (LENT-SOMA) scores 
      were recorded before and after treatment. RESULTS: The mean LENT-SOMA scores 
      before and after HBOT were 11.7 (SD 5.3) and 8.1 (5.1) respectively. This 
      reduction in score of 3.7 (95% CI 2.6 to 4.8) was statistically significant (P < 
      0.001). For radiation cystitis the mean reduction was 3.7 (95% CI 2.4 to 5.0, P < 
      0.001) and for radiation proctitis was 3.8 (95% CI 1.4 to 6.1, P = 0.004). There 
      were no significant adverse effects recorded. CONCLUSIONS: Hyperbaric oxygen 
      treatment may be an effective and safe treatment for pelvic late tissue radiation 
      injury.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Andren, James
AU  - Andren J
AD  - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney, 
      Australia.
AD  - Corresponding author: Dr James Andren, 4 Adelaide Place, Canterbury CT1 2QA, 
      England, jandren@doctors.org.uk.
FAU - Bennett, Michael H
AU  - Bennett MH
AD  - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney, 
      Australia.
AD  - Prince of Wales Clinical School, University of New South Wales, Sydney, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Oxygen
MH  - Prospective Studies
MH  - *Radiation Injuries/therapy
MH  - Retrospective Studies
PMC - PMC7819726
OTO - NOTNLM
OT  - Cancer
OT  - Endothelium
OT  - Gastro-intestinal tract
OT  - Genito-urinary tract
OT  - Pain
OT  - Soft-tissue radionecrosis
COIS- Conflicts of interest and funding: nil
EDAT- 2020/09/22 06:00
MHDA- 2020/11/11 06:00
PMCR- 2021/09/30
CRDT- 2020/09/21 20:22
PHST- 2020/01/19 00:00 [received]
PHST- 2020/06/09 00:00 [accepted]
PHST- 2020/09/21 20:22 [entrez]
PHST- 2020/09/22 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.28920/dhm50.3.250-255 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2020 Sep 30;50(3):250-255. doi: 10.28920/dhm50.3.250-255.